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Merck
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C0412

Sigma-Aldrich

Concanavalin A from Canavalia ensiformis (Jack bean)

Type IV-S, lyophilized powder, γ-irradiated, BioReagent, suitable for cell culture

Sinonimo/i:

Con A

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About This Item

Numero CAS:
11028-71-0
Numero CE:
234-258-2
Numero MDL:
MFCD00071069
Codice UNSPSC:
23151817
NACRES:
NA.32

Livello qualitativo

200

Sterilità

γ-irradiated

Tipo

Type IV-S

Nome Commerciale

BioReagent

Forma fisica

lyophilized powder

tecniche

cell culture | mammalian: suitable

Impurezze

salt, essentially free

Solubilità

PBS: 5 mg/mL, slightly hazy
H2O: soluble, slightly hazy

Temperatura di conservazione

−20°C

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Applicazioni

Concanavalin A from Canavalia ensiformis (jack bean) has been used:
  • to induce spleen blastogenesis
  • to generate ConA blast targets from B6 and lpr spleen cells
  • to stimulate splenic lymphocytes from estrogen-and placebo-treated mice

Azioni biochim/fisiol

Con A is not blood group specific but has an affinity for terminal α-D-mannosyl and α-D-glucosyl residues. Ca2+ and Mn2+ ions are required for activity. Con A dissociates into dimers at pH 5.6 or below. Between pH 5.8 and pH 7.0, Con A exists as a tetramer; above pH 7.0 higher aggregates are formed. Con A exhibits mitogenic activity which is dependent on its degree of aggregation. Succinylation results in an active dimeric form which remains a dimer above pH 5.6.

Risultati analitici

Where reported, agglutination activity is expressed in μg/ml and is determined from serial dilutions in phosphate buffered saline, pH 6.8, containing Ca2+ and Mn2+ of a 1 mg per mL solution. This activity is the lowest concentration to agglutinate a 2% suspension of human erythrocytes after 1 hr incubation at 25 °C.

Pittogrammi

Health hazard
GHS08

Avvertenze

Danger

Indicazioni di pericolo

H317,H334,H361

Classi di pericolo

Repr. 2 - Resp. Sens. 1 - Skin Sens. 1

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Certificati d'analisi (COA)

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