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A3940

Sigma-Aldrich

1-Aminobenzotriazole

greener alternative

≥98% (TLC), powder, cytochrome P450 inhibitor

Sinonimo/i:

1-Benzotriazolamine, ABT

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About This Item

Formula empirica (notazione di Hill):
C6H6N4
Numero CAS:
1614-12-6
Peso molecolare:
134.14
Beilstein:
607843
Numero MDL:
MFCD00132902
Codice UNSPSC:
12352200
ID PubChem:
24278226
NACRES:
NA.77

product name

1-Aminobenzotriazole,

Saggio

≥98% (TLC)

Livello qualitativo

200

Forma fisica

powder

Punteggio alternativa più verde

old score: 93
new score: 46
Find out more about DOZN™ Scoring

Caratteristiche più verdi

Waste Prevention
Safer Solvents and Auxiliaries
Inherently Safer Chemistry for Accident Prevention
Learn more about the Principles of Green Chemistry.

sustainability

Greener Alternative Product

Punto di fusione

81-84 °C (lit.)

Solubilità

ethanol: 49-51 mg/mL, clear, pale yellow to yellow

Categoria alternativa più verde

, Re-engineered

Stringa SMILE

Nn1nnc2ccccc12

InChI

1S/C6H6N4/c7-10-6-4-2-1-3-5(6)8-9-10/h1-4H,7H2
JCXKHYLLVKZPKE-UHFFFAOYSA-N

Informazioni sul gene

human ... CYP1A2(1544)

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Categorie correlate

Descrizione generale

We are committed to bringing you Greener Alternative Products, which adhere to one of the four categories of Greener Alternatives. This product belongs to category of Re-engineered products, showing key improvements in Green Chemistry Principles “Waste Prevention”, “Safer Solvents and Auxiliaries” and “Inherently Safer Chemistry for Accident Prevention”. Click here to view its DOZN scorecard.

Applicazioni

1-Aminobenzotriazole has been used as a cytochrome P450 inhibitor to study the effects of estrogen on H2O2-induced premature senescence of vascular smooth muscle cells from old rats It has also been used to study the estrogen receptor-mediated effects of 17β-estradiol.

Azioni biochim/fisiol

1-Aminobenzotriazole (1-ABT) is used as an in vitro tool in drug discovery. It can differentiate the P450 from non-P450 enzyme systems. 1-ABT exhibits inhibitory action by covalent alteration of the heme prosthetic group in the P450 enzyme.
Suicide inhibitor of cytochrome P450 and chloroperoxidase.

Pittogrammi

Exclamation mark
GHS07

Avvertenze

Warning

Indicazioni di pericolo

H315,H319,H335

Classi di pericolo

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Organi bersaglio

Respiratory system

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Gloves

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Benzotriazole-5-carboxylic acid 99%

Sigma-Aldrich

304239

Benzotriazole-5-carboxylic acid

(S)-(+)-Mephenytoin solid, ≥98% (HPLC)

Sigma-Aldrich

UC175

(S)-(+)-Mephenytoin

2-Aminobenzothiazole 97%

Sigma-Aldrich

108812

2-Aminobenzothiazole

5-Methyl-1H-benzotriazole 98%

Sigma-Aldrich

196304

5-Methyl-1H-benzotriazole

Elacridar ≥98% (HPLC)

Sigma-Aldrich

SML0486

Elacridar

Antipyrine analytical standard

Supelco

A5882

Antipyrine

4-AMINO-3-METHOXYAZOBENZENE AldrichCPR

S805106

4-AMINO-3-METHOXYAZOBENZENE

M Lizeth Orozco Morales et al.
iScience, 25(1), 103571-103571 (2022-01-06)
Mesothelioma is a cancer that typically originates in the pleura of the lungs. It rapidly invades the surrounding tissues, causing pain and shortness of breath. We compared cell lines injected either subcutaneously or intrapleurally and found that only the latter
Is 1-aminobenzotriazole an appropriate in vitro tool as a nonspecific cytochrome P450 inactivator?
Linder CD, et al.
Drug Metabolism and Disposition, 37(1), 10-13 (2009)
Effects of estrogen on stress-induced premature senescence of vascular smooth muscle cells: a novel mechanism for the ?time window theory? of menopausal hormone therapy
Zhu C, et al.
Atherosclerosis, 215(2), 294-300 (2011)
Ailette Prieto et al.
Bioresource technology, 102(23), 10987-10995 (2011-09-23)
More than 90% of the antibiotics ciprofloxacin (CIPRO) and norfloxacin (NOR) at 2 mg L(-1) were degraded by Trametes versicolor after 7 days of incubation in malt extract liquid medium. In in vitro assays with purified laccase (16.7 nkat mL(-1))
Shinji Shimizu et al.
Archives of toxicology, 85(4), 347-353 (2010-09-28)
We investigated hepatotoxicity induced by ticlopidine (TIC) in glutathione (GSH)-depleted rats by pre-treatment of a well-known GSH synthesis inhibitor, L-buthionine-S,R-sulfoxinine (BSO). Although sole administration of either TIC or BSO showed no signs of hepatotoxicity, combined administration of TIC with BSO
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