05130

L-Alanine

≥99.0% (NT)

• Sinonimo/i: (S)-2-Aminopropionic acid, L-α-Aminopropionic acid
• Formula empirica (notazione di Hill): C₃H₇NO₂
• Numero CAS: 56-41-7
• Peso molecolare: 89.09
• Beilstein: 1720248
• Numero CE: 200-273-8
• Numero MDL: MFCD00064410
• Codice UNSPSC: 12352209
• eCl@ss: 32160406
• ID PubChem: 329747640
• NACRES: NA.26

Proprietà

• Saggio: ≥99.0% (NT)
• Stato: powder or crystals
• Attività ottica: [α]20/D +14.0±1°, c = 5% in 5 M HCl
• Impurezze: ≤0.3% foreign amino acids
• Residuo alla calcinazione: ≤0.1% (as SO₄)
• Perdita: ≤0.1% loss on drying, 110 °C
• Colore: colorless to white
• Punto di fusione: 314.5 °C
• Solubilità: H₂O: soluble 89.1 g/l at 20 degrees c; diethyl ether: insoluble; ethanol: soluble (cold 80%)
• Anioni in tracce: chloride (Cl^-): ≤50 mg/kg; sulfate (SO₄^2-): ≤50 mg/kg
• Cationi in tracce: Ca: ≤10 mg/kg; Cd: ≤5 mg/kg; Co: ≤5 mg/kg; Cr: ≤5 mg/kg; Cu: ≤5 mg/kg; Fe: ≤5 mg/kg; K: ≤50 mg/kg; Mg: ≤5 mg/kg; Mn: ≤5 mg/kg; NH₄⁺: ≤100 mg/kg; Na: ≤50 mg/kg; Ni: ≤5 mg/kg; Pb: ≤5 mg/kg; Zn: ≤5 mg/kg
• applicazioni: detection; peptide synthesis
• Stringa SMILE: C[C@H](N)C(O)=O
• InChI: 1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1; QNAYBMKLOCPYGJ-REOHCLBHSA-N

Descrizione

Applicazioni

L-Alanine is used as a standard to determine absolute concentration of a protein within a mixture of other proteins measured with SI traceability.[1]

Azioni biochim/fisiol

Alanine is a nonessential amino acid that plays a key role in the glucose-alanine cycle between muscle tissue and the liver. In amino acid-degrading tissues such as muscle, amino groups are pooled as glutamate by transamination reactions. The amino group of glutamate is transferred to pyruvate via alanine aminotransferase, forming alanine and α-ketoglutarate. The alanine is passed into the blood and transported to the liver. This reaction is reversed in the liver where pyruvate can be used in gluconeogenesis to form glucose, which may return to other tissues through the circulatory system. Increased alanine levels correlate with higher blood pressure, energy intake, cholesterol levels, and body mass index.

L-alanine has the ability to promote the expression of ferritin and antioxidant stress proteins, heme oxygenase-1 (HO-1).[2]

Nota sulla preparazione

L-Alanine completely dissolves in water at a concentration of 89.1 g/l at 20°C to yield solution. It is also soluble in 80% ethanol and insoluble in ether.

Altre note

Preparation of 2-chloropropionic acid[3][4]; Reduction of derivatives to the aldehyde[5][6]

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Gloves, type N95 (US)