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04473

Sigma-Aldrich

2,4-Pyridinedicarboxylic acid

≥98.0%

Sinonimo/i:

Lutidinic acid

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About This Item

Formula empirica (notazione di Hill):
C7H5NO4
Numero CAS:
Peso molecolare:
167.12
Beilstein:
131631
Numero CE:
Numero MDL:
Codice UNSPSC:
12352106
ID PubChem:
NACRES:
NA.25

Saggio

≥98.0%
98.0-102.0% (T)

Stringa SMILE

OC(=O)c1ccnc(c1)C(O)=O

InChI

1S/C7H5NO4/c9-6(10)4-1-2-8-5(3-4)7(11)12/h1-3H,(H,9,10)(H,11,12)
MJIVRKPEXXHNJT-UHFFFAOYSA-N

Applicazioni

2,4-Pyridinedicarboxylic acid is an in vitro and in cell inhibitor, as well as a known inhibitor of the histone lysine demethylases. 2,4-Pyridinedicarboxylic acid has been used in a study to determine that ruthenium(II) complexes exert antimetastatic effects on several tumor cell lines in vitro, achieved mostly by the effect on cell adhesion, migration and angiogenesis. . 2,4-Pyridinedicarboxylic acid has been used in a study to develop an assay that represents the first report of a RapidFire mass spectrometery assay for an epigenetics target.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable


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H M Rowe et al.
Applied spectroscopy, 57(5), 532-537 (2003-12-09)
An adaptation of square-wave gated phase-modulation (GPM) fluorimetry allows for self-referenced intensity measurements without the complexity of dual excitation or dual emission wavelengths. This AC technique utilizes square-wave excitation, gated detection, a reference emitter, and a sensor molecule. The theory
Guo-liang Gu et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 71(1), 209-214 (2008-02-19)
Two novel ligands containing two pyridine-2,6-dicarboxylic acid conjugative units, 4-(2-(2,6-dicarbox-ypyridin-4-yl)vinyl)pyridine-2,6-dicarboxylic acid (L1) and 4-(4-(2-(2,6-dicarboxypyridin-4-yl)vinyl)styryl)pyridine-2,6-dicarboxylic acid (L2) and their complexes with Tb(III) have been synthesized and characterized by elemental analysis, IR spectra and NMR. The ligand synthetic route was optimized and
Michael Raghunath et al.
Biochemical and biophysical research communications, 378(4), 766-771 (2008-12-11)
The rapid vascularisation of biomaterials and engineered tissue after implantation is a current unmet need. To this end, we explored the pharmacological option of inducing neovascularisation using compounds that inhibit hypoxia-induced factor-1alpha prolyl hydroxylase. This stabilises hypoxia inducible factor-1alpha and
John R G Sander et al.
Journal of pharmaceutical sciences, 99(9), 3676-3683 (2010-06-25)
We report on a co-crystal of acetaminophen (APAP) and 2,4-pyridinedicarboxylic acid (PDA). The co-crystal was discovered by screening using the solution-mediated phase transformation (SMPT) technique. Despite the bulk solids of each component being white in color, the new co-crystal phase
C K Derian et al.
The Journal of biological chemistry, 264(12), 6615-6618 (1989-04-25)
While a role has been ascribed to the gamma-carboxyglutamate (Gla) residues in vitamin K-dependent coagulation proteins and the enzyme catalyzing this posttranslational modification has been identified and partially characterized, both the functional significance of a second posttranslationally synthesized amino acid

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