5.33642

AMP Deaminase Inhibitor, Cpd3

• Sinonimo/i: AMP Deaminase Inhibitor, Cpd3, (S)-6-(4-(((1-(isoquinolin-8-yl)ethyl)amino)methyl)phenyl)nicotinic acid , AMPD Inhibitor, Cpd3 , AMPD Inhibitor, AMP Deaminase Inhibitor
• Formula empirica (notazione di Hill): C₂₄H₂₁N₃O₂
• Peso molecolare: 383.44
• Codice UNSPSC: 12352200
• NACRES: NA.77

Proprietà

• Saggio: ≥98% (HPLC)
• Livello qualitativo: 100
• Stato: solid
• Potenza: 38 nM IC₅₀
• Produttore/marchio commerciale: Calbiochem^®
• Condizioni di stoccaggio: OK to freeze; protect from light
• Colore: white
• Solubilità: DMSO: 50 mg/mL
• Temperatura di conservazione: 2-8°C

Descrizione

Descrizione generale

A cell-permeable isoquinoline derivative that acts as a specific AMP competitive inhibitor of AMP deaminase (IC₅₀ = 38, 27, and 24 nM for human, rat, and mice, respectively). Potentiates low frequency electrical stimulation induced increase in AMP level, AMP:ATP ratio, and phosphorylation of AMPK (at Thr172), and acetyl-CoA carboxylase (at Ser218) in contracting rat epitrochlearis muscle. However, it does not affect basal AMPK activity and contraction-stimulated glucose uptake. Preincubation with this compound reduces basal IMP levels, but does affect the contraction-induced increases in IMP, adenosine, and inosine in any appreciable manner.

Azioni biochim/fisiol

Cell permeable: yes

Attenzione

Toxicity: Standard Handling (A)

Ricostituzione

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Altre note

Admyre, T., et al. 2014. Chem. Biol.21, 1486.

Note legali

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable