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14-331-M

SGK1 (δ1-59, S422D) Protein, active, 6 µg

Name: SGK1 (δ1-59, S422D) Protein, active, 6 µg
Brand: MM
Price: 554 EUR

Active, N-truncated (missing N-terminal 60 amino acids), His-tagged, human SGK1 fusion protein, containing a S422D mutation, for use in Kinase Assays.

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Taglio della confezione	SKU	Disponibilità	Prezzo
6 μg		Per conoscere la disponibilità, visualizza il carrello	554,00 €
250 μg		Spedizione prevista il22 maggio 2026daMerck S.p.A	3.390,00 €

Informazioni su questo articolo

UNSPSC Code:

12352202

NACRES:

NA.32

eCl@ss:

32160405

Biological source:

human

Mol wt:

M_w 48 kDa

554,00 €

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Proprietà

biological source

human

Quality Level

100, 300

mol wt

M_w 48 kDa

manufacturer/tradename

Upstate^®

technique(s)

activity assay: suitable (kinase)

Descrizione

General description

N-truncated (missing Nterminal 60 amino acids), His-tagged, human SGK1 fusion protein, containing a S422D mutation

Product Source: expressed in Sf21 cells

Biochem/physiol Actions

Protein Target: SGK1

Target Sub-Family: AGC

Physical form

Ni-NTA agarose

Preparation Note

1 year at -70°C

Analysis Note

routinely evaluated by Kinase assay

Other Notes

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Questo articolo	14-502-M	14-346-M	14-329-M
Sigma-Aldrich 14-331-M SGK1 (δ1-59, S422D) Protein, active, 6 µg	Sigma-Aldrich 14-502-M Akt3/PKBγ (S472D) Protein, active, 10 µg	Sigma-Aldrich 14-346-M CHK1 Protein, active, 10 µg	Sigma-Aldrich 14-329-M JNK2α2/SAPK1a Protein, active, 10 µg
technique(s) activity assay: suitable (kinase)	technique(s) activity assay: suitable (kinase)	technique(s) activity assay: suitable (kinase)	technique(s) activity assay: suitable (kinase)
biological source human	biological source human	biological source human	biological source human
mol wt M_w 48 kDa	mol wt M_w 43 kDa	mol wt M_w 81.6 kDa	mol wt M_w 49.2 kDa
Gene Information human ... SGK1(6446)	Gene Information human ... AKT3(10000)	Gene Information human ... CHEK1(1111)	Gene Information human ... MAPK9(5601)
UniProt accession no. O00141	UniProt accession no. Q9Y243	UniProt accession no. O14757	UniProt accession no. P45984
NCBI accession no. NM_005627.2	NCBI accession no. NM_005465.3, NM_181690.1	NCBI accession no. NM_001274.3	NCBI accession no. NM_002752.3, NM_139068.1, NM_139069.1, NM_139070.1

pictograms

GHS07

signalword

Warning

hcodes

H317

pcodes

P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364

Hazard Classifications

Skin Sens. 1

Classe di stoccaggio

10 - Combustible liquids

wgk

WGK 2

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Activation of NHE3 by dexamethasone requires phosphorylation of NHE3 at Ser663 by SGK1

Wang, Dongsheng, et al

American Journal of Physiology. Cell Physiology, 289, C802-C810 (2005)

Cell surface expression of the ROMK (Kir 1.1) channel is regulated by the aldosterone-induced kinase, SGK-1, and protein kinase A.

Dana Yoo et al.

The Journal of biological chemistry, 278(25), 23066-23075 (2003-04-10)

The Kir1.1 (ROMK) subtypes of inward rectifier K+ channels mediate potassium secretion and regulate sodium chloride reabsorption in the kidney. The density of ROMK channels on the cortical collecting duct apical membrane is exquisitely regulated in concert with physiological demands.

Characterization of the structure and regulation of two novel isoforms of serum- and glucocorticoid-induced protein kinase.

T Kobayashi et al.

The Biochemical journal, 344 Pt 1, 189-197 (1999-11-05)

The catalytic domain of serum- and glucocorticoid-induced protein kinase (SGK) is 54% identical with protein kinase B (PKB) and, like PKB, is activated in vitro by 3-phosphoinositide-dependent protein kinase-1 (PDK1) and in vivo in response to signals that activate phosphatidylinositol

Numero articolo commerciale globale

SKU	GTIN
14-331M	04053252924095
14-331	04053252328633

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