The concentration in milligrams per milliliter (mg/mL) depends on the lot. For C8554, which comes in 50 IU per vial, if the specific activity is 5807 IU/mg as indicated in the CoA, dividing this number by 50 IU yields a mass of 8.6 µg. With 1 mL, the concentration would be 8.6 µg/mL.
C8554
绒毛膜促性腺激素 人
lyophilized powder, suitable for mouse embryo cell culture
同義詞:
HCG, 绒毛膜促性腺激素
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Biological source:
human urine
Form:
lyophilized powder
暫時無法取得訂價和供貨情況
biological source
human urine
Quality Segment
sterility
aseptically processed
form
lyophilized powder
potency
≥5,000 I.U. per mg
mol wt
37.9 kDa, apparent mol wt 37.9 kDa by SDS-PAGE
drug control
Home Office Schedule 4.2
technique(s)
cell culture | embryo: suitable
impurities
HBV,HCV and HIV, tested negative
solubility
H2O: 1 mL/vial, saline: 1 mL/vial
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
Gene Information
human ... CGA(1081)
General description
注意：根据糖基化程度的不同，实际分子量与理论值不同。该物质天然形式的理论分子量为 37.9kDa，且包含 2 个亚基：α = 14.9kDa（多肽部分 ~10.2kDa，碳水化合物部分 ~4.7kDa），β = 23.0kDa（多肽部分 ~16.0kDa，碳水化合物部分 ~7.0kDa）。参见 J. Biol. Chem. 248，6796-6827(1973)。
由 92 个氨基酸 α 链组成的糖蛋白激素，与 LH、FSH 和 TSH 相同； 和一个独特的 149 个氨基酸 β 链。由绒毛膜组织产生，负责在妊娠早期维持黄体。也由滋养层细胞肿瘤产生，其特征是游离 hCG β-链升高和高糖基化 hCG。
Application
推荐用于小鼠的超数排卵诱导。
Biochem/physiol Actions
Human chorionic gondadotropin (hCG) may be used as an alternative to PMSG to induce ovulation in laboratory animals.[1] When hCG was injected into laboratory animals via intravenous (i.v.), intraperitoneal (i.p.), or subcutaneous (s.c.) methodstet, the effective dose values for 50% of the animals (ED50) per animal and per body weight (kg) in parenthesis were as follows:
Mice: i.v. 0.2 (7.7) I.U.; i.p. 0.3 (11.5) I.U.; s.c. 0.7 (26.9) I.U.
Syrian hamsters: i.v. 1.0 (9.5) I.U.; i.p. 1.8 (17.1) I.U.; s.c. 2.6 (24.8) I.U.
Rats: i.v. 1.3 (4.6) I.U.; i.p. 3.5 (12.3) I.U.; s.c.7.5 (26.3) I.U.
Using PMSG, the ED50 values per animal and per body weight (kg) in parenthesis were as follows:
Mice: i.v. 0.8 (30.8) I.U.; i.p. 2.0 (76.9) I.U.; s.c. 2.8 (107.7) I.U
Syrian hamsters: i.v., 3.6 (34.3) I.U.; i. p., 8.0 (76.2) I.U.; s.c., 13.2 (125.7) I.U.
Rats: i.v., 6.0 (76.8) I.U.; i p., 20.8 (73.0) I.U.; s.c., 76.8 (269.5) I.U.
Mice: i.v. 0.2 (7.7) I.U.; i.p. 0.3 (11.5) I.U.; s.c. 0.7 (26.9) I.U.
Syrian hamsters: i.v. 1.0 (9.5) I.U.; i.p. 1.8 (17.1) I.U.; s.c. 2.6 (24.8) I.U.
Rats: i.v. 1.3 (4.6) I.U.; i.p. 3.5 (12.3) I.U.; s.c.7.5 (26.3) I.U.
Using PMSG, the ED50 values per animal and per body weight (kg) in parenthesis were as follows:
Mice: i.v. 0.8 (30.8) I.U.; i.p. 2.0 (76.9) I.U.; s.c. 2.8 (107.7) I.U
Syrian hamsters: i.v., 3.6 (34.3) I.U.; i. p., 8.0 (76.2) I.U.; s.c., 13.2 (125.7) I.U.
Rats: i.v., 6.0 (76.8) I.U.; i p., 20.8 (73.0) I.U.; s.c., 76.8 (269.5) I.U.
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本產品 | |||
|---|---|---|---|
| biological source human urine | biological source human urine | biological source human urine | biological source human |
| Quality Level 200 | Quality Level 200 | Quality Level 200 | Quality Level 100 |
| technique(s) cell culture | embryo: suitable | technique(s) - | technique(s) - | technique(s) - |
| form lyophilized powder | form lyophilized powder | form lyophilized powder | form solid |
| Gene Information human ... CGA(1081) | Gene Information human ... CGA(1081) | Gene Information human ... CGA(1081) | Gene Information - |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. −20°C |
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Could you provide the concentration of C8554 in milligrams per milliliter (mg/ml)?
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