細胞保留
在提高生產效率和降低製造成本的同時，提高靈活性的壓力與日俱增，這驅動了人們對灌流的重新興趣。灌注操作可提供高密度細胞培養，減輕處理大量生產生物反應器的負擔。
增加您的細胞密度、生產力及彈性
使用 Cellicon® Cell Retention 解決方案，可大幅提高活細胞密度，同時改善您的上游生產力及製造彈性。結合您的 透過持續移除用過的培養基，並溫和地保留大量有活力的細胞，強化您的上游。
了解如何使用 Cellicon® Cell Retention Solution 強化種子列，幫助您達到更高的細胞密度、縮短處理時間和步驟數量，以獲得更高的製造彈性和產量。瞭解如何輕鬆整合至您的上游灌注製程。
Cellicon®細胞保留解決方案的主要優點
- 可使灌注製程達到更高的細胞密度
- 可靠且可重複的效能高通量和低堵塞
- 全面監測和精確控制
- 可預測的從台式到製造規模的線性擴展
- 易於使用和安裝
實驗室規模 Cellicon® 細胞保留解決方案 ® 平板一次性過濾器組件和控制器組成，可滿足您的灌流 種子培養 需求。控制器可顯示直觀的管道與儀器圖 (P&ID)，讓使用者能立即看到所有製程參數。這個實驗室規模的解決方案非常適合您的製程開發、放大和縮小工作。
製程規模的 Cellicon® Cell Retention Solution 包括 Cellicon® Filter Assembly 和 Mobius® Cell Retention System。sup>® 過濾器組件和Mobius® 細胞保留系統，以及Bio4C ACE™控制軟體。提供 50、200、500、1000 及 2000 L 尺寸，此簡單易用的解決方案可確保可預測的效能及線性擴充能力。Bio4C ACE™ 控制軟體可進行手動處理，也可透過配方進行自動處理；該軟體有助於符合 21 CFR Part 11 和 EudraLex Volume 4 Annex 11 規範，滿足您的臨床和商業製程需求。此解決方案可輕鬆連接至任何生物反應器：所有 Cellicon® 過濾器組件可焊接至任何生物反應器袋上，您也可以選擇使用無菌接頭。
相關產品資源
- Data Sheet: Cellicon® Filter and Controller
The benchtop Cellicon™ Perfusion Solution is designed to meet your perfused seed train challenges. It consists of a controller and a flat sheet cell retention filter with a single-use assembly running in tangential flow filtration mode. This easy-to-use solution increases perfusion process efficiency and provides real-time monitoring and control for reliable and consistent performance.
- Data Sheet: Cellicon® Cell Retention Solution for Process Scale
Embark on a journey of discovery as you delve into a wealth of technical insights and specifications, gaining a comprehensive understanding of the product's vast capabilities and unlocking its limitless potential.
- Cell Retention Technology and Specialized Cell Culture Media for Intensified Upstream Processing
This study demonstrates the use of a Cellicon® filter and controller in an N-1 perfusion process with Cellvento® 4CHO-X expansion medium as compared to a control seed train using shake flasks
- Reproducible Scaling of a Cell Retention Filter Using the Cellicon® Cell Retention Solution
This page describes the design attributes of the Cellicon® Filter Assembly and how they simplify process scale-up.
- Operational and Financial Advantages of Cellicon® Cell Retention Solution in an N-1 Perfusion Process
The following study compares the process economics of an N-1 perfusion process at the 2,000 L scale using our Cellicon® Cell Retention Solution versus a commercially available cell retention device
- Performance Guide: Cellicon® Perfusion Solution
Process Recommendations and Scalability Strategies for Optimization of Perfusion Cell Culture with the Cellicon® Cell Retention Solution
- Application Note: Evaluation of Novel Cell Retention Technology and Cell Culture Media for N-1 Perfused Seed Train
This study was designed to evaluate new technologies and explore the benefits of process intensification in an N-1 perfusion application. It used the Cellicon™ perfusion filter and controller, as well as the Cellvento® 4CHO-X Expansion Medium during cell expansion. The products were evaluated based on the metrics of cell growth, viability, titer, nutrient quantities, and product quality.
- Data Sheet: Bio4C ACE™ Control Software
This data sheet outlines the features and benefits of Bio4C ACE™ software.
- White Paper: Upstream Intensification – Enabling Perfusion Processes with Cell Retention Technologies
In this white paper, we explore perfusion processes and how they are becoming a viable solution that can be used to address today’s processing challenges by increasing speed, reducing plant footprint, and improving productivity without compromising product quality.
- White Paper: A Cost Analysis and Evaluation of Perfused Seed Train Scenarios Through Process Modeling
This white paper describes process modeling and comparison of process economics for a conventional upstream process and three perfused seed train alternatives in combination with either a conventional fed-batch bioreactor or high-seed fed-batch bioreactor.
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