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C-H 功能化

C-H官能化被稱為合成有機化學的聖杯。1   最近,有機化學、有機金屬和催化等領域在理解C-H鍵的反應性以及利用這種洞察力開發強大反應方面都取得了重大進展,這表明將這些策略廣泛引入逆合成詞彙的時機已成熟。2-11 以選擇性和可控制的方式將 C-H 轉換成 C-C、C-N、C-O 或 C-X 鍵的可靠且可預測的轉換,對步驟經濟性和減少廢棄物非常有利。   

C-H活化的新方法擴大了特定分子中可針對的位點數量,增加了將其細緻化為更複雜產品的機會。此外,它還可以在有機合成中針對完全不同種類的化學鍵,特別是具有高化學選擇性的化學鍵。結合傳統的官能基化學,C-H 官能化可大幅簡化複雜天然產品和醫藥化合物的化學合成過程。雖然 C-H 功能化邏輯的應用有明顯的優勢,12 許多有機化學的課程尚未更新以反映此方法,進一步的資訊可在 C-H 功能化手冊。


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參考資料

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