強化與連續的下游製程
在減少佔用空間和成本的同時，獲得作業效率和彈性
希望提高下游製程效率嗎？
由於對新療法的需求，加上需要降低成本，同時確保操作的靈活性和生產力，因此加速了生物製造工作流程的變革。
製程強化、封閉和連續生物製程是實現這些目標的基本策略。
為了協助生物製藥製造商強化、封閉、數位化增強或完全連續其製程，並獲得新水準的營運效率與彈性，DSP 套件中提供了多種槓桿。
強化與連續的下游 (DSP) 處理
無論您要開發強化或連續性生物製程，我們都能提供先進的下游製程技術，協助您達成純化目標。
相關類別
單次使用和多次使用色譜系統對於分離您有價值的分子至關重要。
親和層析通常用於俘虜階段，以分離目標分子並減少處理量。
離子交換 (IEX) 色層法基於目標分子與色層樹脂之間的電荷差分離生物分子。
使用膜層析技術進行捕捉和拋光，優化下游淨化。Natrix 膜提高了經濟性和設備效率。
提升過濾精度：我們的切向流製程產品可確保 mAbs、疫苗等產品的純度，從單次使用擴展至多次使用。
相關資源
- What is Multi Column Chromatography?
In this article, we will discuss one of the methods used to intensify the capture chromatography process: multi column chromatography (MCC).
- Mobius® Multi Column Capture System
The Mobius® Multi Column Capture system is designed as a fully automated, single-use solution to operate continuous closed capture chromatography.
- App Note: Multi Column Capture
Results from the multi-column capture (MCC) system implementation as part of a fully integrated downstream continuous manufacturing platform are reported here.
- Intensified Polishing Using Single-Pass Tangential Flow Filtration (SPTFF) with Anion Exchange Chromatography
In this app note, SPTFF preconcentration is used to intensify the anion exchange (AEX) polishing step in monoclonal antibody (mAb) processing for improved impurity removal and column productivity.
- Brochure: Process Development and Drug Manufacturing: Support Services
We provide comprehensive services for drug development and manufacturing, including technical and regulatory expertise and process development support.
- Article: pDADMAC Flocculation in Monoclonal Antibody Production Processes – Overcoming Regulatory Challenges with Quality Risk Management
Flocculants, like pDADMAC, remove cell debris during downstream monoclonal antibody production, but their adoption has been difficult due to perceived regulatory concerns.
相關網路研討會
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