CG5

绒毛膜促性腺激素 人

lyophilized powder, vial of ~5,000 IU

• 同義詞: HCG, 绒毛膜促性腺激素
• CAS號碼: 9002-61-3
• EC號碼: 232-660-2
• MDL號碼: MFCD00130797
• 分類程式碼代碼: 12352209
• NACRES: NA.32

屬性

• 生物源: human urine
• 無菌: sterile-filtered
• 形狀: lyophilized powder
• 分子量: 37.9 kDa
• 包含: mannitol
• 包裝: vial of ~5,000 IU
• drug control: Home Office Schedule 4.2
• 雜質: HBsAg, HCV and HIV-1/HIV-2, tested negative
• 溶解度: water: 10 mL/vial, clear to slightly hazy, colorless
• UniProt登錄號: P01215
• 運輸包裝: ambient
• 儲存溫度: −20°C
• 基因資訊: human ... CGA(1081)

描述

一般說明

由 92 个氨基酸 α 链组成的糖蛋白激素，与 LH、FSH 和 TSH 相同； 和一个独特的 149 个氨基酸 β 链。由绒毛膜组织产生，负责在妊娠早期维持黄体。也由滋养层细胞肿瘤产生，其特征是游离 hCG β-链升高和高糖基化 hCG。

Chorionic gonadotropin human (CGA or hCG) is a heterodimer and belongs to the cystine knot growth factor superfamily. It exists as six variants namely hCGn, hCGβ, hCGβn, hCGβcf and hCGα including hCG. CGA is mapped to human chromosome 6q14.3. hCG comprises of α and β chain.

應用

Chorionic gonadotropin human has been used:

• to induce oocyte maturation in cultured follicles
• along with pregnant mare serum gonadotropin (PMSG) to induce superovulation in mice
• as medium component for fetal testes culture to aid steroidogenic responsiveness

生化／生理作用

Elevated levels of hCG is observed in trophoblastic cancer. hCG levels are indicators of pregnancy and β subunit is majorly present in urine samples. hCG isoform detection is useful in the diagnosis and management of trophoblastic related diseases including carcinomas.

重構

When reconstituted with water to a concentration of 1,000 IU/mL, the vial will also contain 0.1 M sodium phosphate buffer (pH approx. 7.2) and 100 mg/mL of mannitol.

分析報告

The calculated value is based on the USP method for human Chorionic Gonadotrophin, to meet 5,000 IU per vial, with a tolerance of not less than 80.0% and not more than 125.0% of the potency stated.

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 2
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable