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E2011
顺式-5,8,11,14,17-二十碳五烯酸
from fish oil, ≥99% (GC), liquid, 5-Lipoxygenase inhibitor
cis-5,8,11,14,17-Eicosapentaenoic acid
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同義詞:
EPA, 二十碳五烯酸
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線性公式:
CH3(CH2CH=CH)5(CH2)3CO2H
CAS 編號:
分子量：:
302.45
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352211
MDL number:
Beilstein/REAXYS Number:
1714433
Assay:
≥99%
Form:
liquid
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產品名稱
顺式-5,8,11,14,17-二十碳五烯酸, ≥99%
biological source
fish oil
Quality Segment
assay
≥99%
form
liquid
refractive index
n20/D 1.4977 (lit.)
mp
−54-−53 °C (lit.)
solubility
methanol: 50 mg/mL, clear, colorless
density
0.943 g/mL at 25 °C (lit.)
storage temp.
−20°C
SMILES string
CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCCC(O)=O
InChI
1S/C20H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h3-4,6-7,9-10,12-13,15-16H,2,5,8,11,14,17-19H2,1H3,(H,21,22)/b4-3-,7-6-,10-9-,13-12-,16-15-
InChI key
JAZBEHYOTPTENJ-JLNKQSITSA-N
Gene Information
human ... ALOX5(240)
mouse ... ALOX5(11689), Pparg(19016)
rat ... ALOX5(25290)
General description
二十碳五烯酸是通过亚麻酸合成的多不饱和脂肪酸(PUFA)。它分布于细胞膜的磷脂双分子层、大脑突触膜和视网膜中。它主要来源于鱼油、海草、浮游植物和亚麻荠。作为ω-3脂肪酸，它具有顺反构象。
Application
顺式-5,8,11,14,17-二十碳五烯酸已用于：
- 检测其对肝细胞脂肪变性的药理作用
- 作为拉曼光谱法的分析标准品表征人乳腺癌样本
- 小鼠胚胎成纤维细胞的脂质过氧化分析和细胞活性检测中的细胞预处理
Biochem/physiol Actions
5-脂氧合酶抑制剂；减少凝血噁烷 A2 生成。
二十碳五烯酸(EPA)是健康生活的必需脂肪酸，并且可缓解肥胖症。它可通过调节极低密度脂蛋白(VLDL)水平来降低甘油三酯水平。
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本產品 | |||
|---|---|---|---|
| assay ≥99% | assay ≥98.5% (GC) | assay ≥99% (capillary GC) | assay ≥99% |
| form liquid | form - | form film or powder | form - |
| Quality Level 200 | Quality Level 100 | Quality Level 200 | Quality Level 200 |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. −20°C |
| solubility methanol: 50 mg/mL, clear, colorless | solubility - | solubility methanol: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow | solubility - |
| refractive index n20/D 1.4977 (lit.) | refractive index n20/D 1.4977 (lit.) | refractive index - | refractive index n20/D 1.480 (lit.) |
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wgk
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flash_point_f
200.1 °F - closed cup
flash_point_c
93.4 °C - closed cup
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