D1069
地氯雷他定
≥98% (HPLC), histamine H1 receptor antagonist, powder
同義詞:
8-Chloro-6,11-dihydro-11-(4-piperidinylidene)-5H- benzo[5,6]cyclohepta[1,2,b]pyridine, Clarinex®
登入 檢視組織與合約價格。
選擇尺寸
關於此項目
經驗公式（希爾表示法）:
C19H19ClN2
CAS 編號:
分子量：:
310.82
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.32
MDL number:
產品名稱
地氯雷他定, powder, ≥98% (HPLC)
Quality Level
assay
≥98% (HPLC)
form
powder
solubility
DMSO: >10 mg/mL
storage temp.
2-8°C
SMILES string
Clc1ccc2c(CCc3cccnc3\C2=C4\CCNCC4)c1
InChI
1S/C19H19ClN2/c20-16-5-6-17-15(12-16)4-3-14-2-1-9-22-19(14)18(17)13-7-10-21-11-8-13/h1-2,5-6,9,12,21H,3-4,7-8,10-11H2
InChI key
JAUOIFJMECXRGI-UHFFFAOYSA-N
Gene Information
human ... HRH1(3269)
尋找類似的產品？ 前往 產品比較指南
相關類別
Application
Desloratadine has been used to test its effect on embryoid body development in in vitro gastrulation model of P19C5 stem cells. It has also been used as an antihistamine mimic in rats and to treat lung cancer (A549) and glioblastoma (U87) cells in various cellular studies.
Biochem/physiol Actions
A non-sedating H1-receptor antagonist, free from antimuscarinic/anticholinergic effects. It has novel antiallergic and anti-inflammatory effects.
Desloratadine is a selective and nonsedating histamine H1 receptor antagonist, an active metabolite of loratadine (Claritin), used to relieve hay fever and allergy symptoms with less drowsiness than other antihistamines; does not significantly inhibits cardiac K+ channels at clinically achievable blood levels. Free from antimuscarinic/anticholinergic effects.
Legal Information
Clarinex is a registered trademark of Schering Corp.
存儲類別/等級
11 - Combustible Solids
wgk
WGK 1
flash_point_f
390.2 °F - Pensky-Martens closed cup
flash_point_c
199 °C - Pensky-Martens closed cup
Lysosomal Destabilizing Drug Siramesine and the Dual Tyrosine Kinase Inhibitor Lapatinib Induce a Synergistic Ferroptosis through Reduced Heme Oxygenase-1 (HO-1) Levels
Villalpando-Rodriguez GE, et al.
Oxidative Medicine and Cellular Longevity, 2019 (2019)
Translational Physiology: Prolonged intake of desloratadine: mesenteric lymphatic vessel dysfunction and development of obesity/metabolic syndrome
Gasheva OY, et al.
The American Journal of Physiology, 316(1), G217-G217 (2019)
Nicholas Cutrona et al.
ACS infectious diseases, 5(8), 1397-1410 (2019-05-28)
Staphylococcus epidermidis and Staphylococcus aureus are important human pathogens responsible for two-thirds of all postsurgical infections of indwelling medical devices. Staphylococci form robust biofilms that provide a reservoir for chronic infection, and antibiotic-resistant isolates are increasingly common in both healthcare
Exposure-based validation of an in vitro gastrulation model for developmental toxicity assays
Warkus ELL and Marikawa Y
Toxicological Sciences, 157(1), 235-245 (2017)
Tomomi Aida et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 40(7), 1569-1579 (2015-02-11)
An increase in the ratio of cellular excitation to inhibition (E/I ratio) has been proposed to underlie the pathogenesis of neuropsychiatric disorders, such as autism spectrum disorders (ASD), obsessive-compulsive disorder (OCD), and Tourette's syndrome (TS). A proper E/I ratio is
相關內容
我們的科學家團隊在所有研究領域都有豐富的經驗，包括生命科學、材料科學、化學合成、色譜、分析等.
聯絡技術服務