P0052
PNU-74654
≥98% (HPLC), solid
Sinonimo/i:
Benzoic acid, 2-phenoxy-, 2-[(5-methyl-2-furanyl)methylene]hydrazide
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Cambia visualizzazione
| Taglio della confezione | SKU | Disponibilità | Prezzo |
|---|---|---|---|
| 5 mg | Per conoscere la disponibilità, visualizza il carrello | CHF 128.00 | |
| 25 mg | Per conoscere la disponibilità, visualizza il carrello | CHF 504.00 |
Informazioni su questo articolo
Formula empirica (notazione di Hill):
C19H16N2O3
Numero CAS:
Peso molecolare:
320.34
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352203
MDL number:
Servizio Tecnico
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Permettici di aiutartiQuality Level
assay
≥98% (HPLC)
form
solid
color
white to off-white
solubility
DMSO: >10 mg/mL
storage temp.
2-8°C
SMILES string
Cc1ccc(\C=N\NC(=O)c2ccccc2Oc3ccccc3)o1
InChI
1S/C19H16N2O3/c1-14-11-12-16(23-14)13-20-21-19(22)17-9-5-6-10-18(17)24-15-7-3-2-4-8-15/h2-13H,1H3,(H,21,22)/b20-13+
InChI key
JJEDWBQZCRESJL-DEDYPNTBSA-N
Application
PNU-74654 has been used:
- as a β-catenin signaling inhibitor to study its effects on the funnel cartilage differentiation in Sepia sp. embryos[1]
- as a Wnt signaling inhibitor to study its effects on glycogen synthase kinase 3β (GSK-3β) inhibition in prostate cancer cell lines[2]
- as a Wnt signaling inhibitor to study its effects on leptin-induced cell proliferation in breast cancer cells[3]
Biochem/physiol Actions
PNU-74654 inhibits the Wnt-β catenin pathway by blocking the interaction between β-catenin and TCF (T cell factor). It is also an anti-tumor agent.
PNU-74654 inhibits the Wnt-β catenin pathway by blocking the interaction between β-catenin and TCF (T cell factor). PNU-74654 is also an anti-tumor agent. Aberrant activation of the Wnt/β-catenin pathway (canonical pathway) is implicated in driving development/progression of different tumors, such as colon cancer, through interaction between β-catenin and T cell factor (TCF), which regulates the expression of target genes in cell proliferation and differentiation. Inhibition of this pathway activity in cancer cell lines efficiently blocks their growth. PNU-74654 inhibits this pathway by blocking the interaction between β-catenin and TCF.
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Questo articolo | |||
|---|---|---|---|
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) |
| form solid | form powder | form powder | form powder |
| Quality Level 100 | Quality Level 100 | Quality Level - | Quality Level 100 |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
| solubility DMSO: >10 mg/mL | solubility DMSO: 2 mg/mL, clear | solubility DMSO: 15 mg/mL, clear | solubility DMSO: >25 mg/mL |
| color white to off-white | color light yellow to dark orange | color white to brown | color red to brown |
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
Classe di stoccaggio
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Jieun Lee et al.
Biochemical and biophysical research communications, 525(3), 563-569 (2020-03-03)
Supercentenarians (≥110-year-old, SC) are a uniquely informative population not only because they surpass centenarians in age, but because they appear to age more slowly with fewer incidences of chronic age-related disease than centenarians. We reprogramed donor B-lymphoblastoid cell lines (LCL)
Jan Kroon et al.
Oncotarget, 5(19), 8986-8994 (2014-10-27)
Cancer cells with stem or progenitor properties play a pivotal role in the initiation, recurrence and metastatic potential of solid tumors, including those of the human prostate. Cancer stem cells are generally more resistant to conventional therapies thus requiring the
Oscar A Tarazona et al.
Nature, 533(7601), 86-89 (2016-04-26)
The evolution of novel cell types led to the emergence of new tissues and organs during the diversification of animals. The origin of the chondrocyte, the cell type that synthesizes cartilage matrix, was central to the evolution of the vertebrate
Numero articolo commerciale globale
| SKU | GTIN |
|---|---|
| P0052-5MG | 04061833220047 |
| P0052-25MG | 04061833220030 |