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M4002

6-Methylmercaptopurine riboside

≥99% (HPLC), synthetic (organic), powder

Sinonimo/i:

6MMPr, 6-(Methylthio)-9-β-D-ribofuranosyl-9H-purine

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Cambia visualizzazione
Taglio della confezioneSKUDisponibilitàPrezzo
1 g
Per conoscere la disponibilità, visualizza il carrello
CHF 341.00

Informazioni su questo articolo

Formula empirica (notazione di Hill):
C11H14N4O4S
Numero CAS:
342-69-8
Peso molecolare:
298.32
UNSPSC Code:
41106305
PubChem Substance ID:
24896894
NACRES:
NA.51
EC Number:
206-442-2
Assay:
≥99% (HPLC)
Biological source:
synthetic (organic)
Form:
powder
Solubility:
methanol: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow
Storage temp.:
−20°C

CHF 341.00

Per conoscere la disponibilità, visualizza il carrello
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Nome del prodotto

6-Methylmercaptopurine riboside, ≥99% (HPLC)

biological source

synthetic (organic)

Quality Level

200

assay

≥99% (HPLC)

form

powder

solubility

methanol: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow

storage temp.

−20°C

SMILES string

O[C@H]([C@@H](CO)O1)[C@@H](O)[C@@H]1N2C=NC3=C(SC)N=CN=C32

InChI

1S/C11H14N4O4S/c1-20-10-6-9(12-3-13-10)15(4-14-6)11-8(18)7(17)5(2-16)19-11/h3-5,7-8,11,16-18H,2H2,1H3

InChI key

ZDRFDHHANOYUTE-UHFFFAOYSA-N

Application

6-Methylmercaptopurine riboside (6MMPR) has been used as a phosphoribosyl pyrophosphate amidotransferase inhibitor to study its effects on DNA replication in a retinoblastoma (Rb) phosphorylation-independent manner in human cytomegalovirus (HCMV) , as a purine analog to determine its effects on angiogenesis of endothelial cells induced by fibroblast growth factor 2 (FGF2) in vitro and in vivo[1], as a metabolite of 6-methylmercaptopurine to determine its levels in human plasma by high-performance liquid chromatography (HPLC) method .
6-Methylmercaptopurine riboside (6MMPr) is used in studies on thiopurine metabolism by enzymes such as inosine-5′-monophosphate dehydrogenase and thiopurine methyltransferase. 6MMPr may also be used to study mechanisms of bovine viral diarrhea virus (BVDV) inhibition.

Biochem/physiol Actions

6-Methylmercaptopurine riboside (6MMPR) is a modified thiopurine nucleoside involved in the inhibition of purine synthesis. It exhibits anti-viral effects against various viruses. 6MMPR is an analog of purine and an inhibitor of nerve growth factor-activated protein kinase N.[1]

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Questo articolo
B7877D5287D5412
6-Methylmercaptopurine riboside ≥99% (HPLC)

Sigma-Aldrich

M4002

6-Methylmercaptopurine riboside

6-Bromo-2-naphthyl β-D-glucopyranoside ≥99% (TLC)

Sigma-Aldrich

B7877

6-Bromo-2-naphthyl β-D-glucopyranoside

2′-Deoxyinosine ≥98%

Sigma-Aldrich

D5287

2′-Deoxyinosine

2′-Deoxyuridine ≥98.5%

Sigma-Aldrich

D5412

2′-Deoxyuridine

biological source

synthetic (organic)

biological source

-

biological source

synthetic (organic)

biological source

synthetic (organic)

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

300

assay

≥99% (HPLC)

assay

≥99% (TLC)

assay

≥98%

assay

≥98.5%

form

powder

form

powder

form

powder

form

powder

solubility

methanol: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow

solubility

pyridine: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow

solubility

1 M NH4OH: 50 mg/mL, clear, colorless

solubility

water: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

-

Classe di stoccaggio

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificati d'analisi (COA)

Lot/Batch Number
0000549629
0000549630
0000549630
0000549629
0000494914

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Ulf Hindorf et al.
Journal of hepatology, 52(1), 106-111 (2009-11-13)
Corticosteroids alone or in conjunction with azathioprine (AZA) is the standard treatment in autoimmune hepatitis (AiH). Individual variations in thiopurine (TP) metabolism may affect both drug efficacy and toxicity. Our aim was to investigate the utility of thiopurine methyltransferase (TPMT)
P R Wielinga et al.
Molecular pharmacology, 62(6), 1321-1331 (2002-11-19)
Mercaptopurines have been used as anticancer agents for more than 40 years, and most acute lymphoblastic leukemias are treated with 6-mercaptopurine (6MP) or 6-thioguanine (TG). Overexpression of the two related multidrug resistance proteins MRP4 and MRP5 has been shown to
M Presta et al.
Cancer research, 59(10), 2417-2424 (1999-05-27)
Angiogenesis has been identified as an important target for antineoplastic therapy. The use of purine analogue antimetabolites in combination chemotherapy of solid tumors has been proposed. To assess the possibility that selected purine analogues may affect tumor neovascularization, 6-methylmercaptopurine riboside
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Numero articolo commerciale globale

SKUGTIN
M4002-1G04061834053644

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