D5287

2′-Deoxyinosine

≥98%

• Sinonimo/i: 9-(2-Deoxy-β-D-ribofuranosyl)hypoxanthine
• Formula empirica (notazione di Hill): C₁₀H₁₂N₄O₄
• Numero CAS: 890-38-0
• Peso molecolare: 252.23
• Beilstein: 33517
• Numero CE: 212-964-1
• Numero MDL: MFCD00005762
• Codice UNSPSC: 41106305
• ID PubChem: 24893935
• NACRES: NA.51

Proprietà

• Origine biologica: synthetic (organic)
• Saggio: ≥98%
• Forma fisica: powder
• Impurezze: inosine, essentially free
• Solubilità: 1 M NH₄OH: 50 mg/mL, clear, colorless
• Temperatura di conservazione: −20°C
• Stringa SMILE: OC[C@H]1O[C@H](C[C@@H]1O)n2cnc3C(=O)NC=Nc23
• InChI: 1S/C10H12N4O4/c15-2-6-5(16)1-7(18-6)14-4-13-8-9(14)11-3-12-10(8)17/h3-7,15-16H,1-2H2,(H,11,12,17)/t5-,6+,7+/m0/s1; VGONTNSXDCQUGY-RRKCRQDMSA-N

Descrizione

Applicazioni

2′-Deoxyinosine has been used in the quantification of nucleoside forms of DNA lesion in a single DNA sample by liquid chromatography tandem mass spectrometry (LC-MS/MS). It has also been used as a standard for high performance liquid chromatography analysis.

Azioni biochim/fisiol

2′-Deoxyinosine is a nucleoside composed of hypoxanthine attached to 2′-deoxyribose via a β-N9-glycosidic bond. 2′-Deoxyinosine in DNA can arise from deamination of adenosine. 2′-deoxyinsine can be used as a model compound to study the chemistry of adduct formation and radical chemistry that may affect DNA structures. 2′-Deoxyinosine is used to produce hybridization-sensitive fluorescent DNA probes with self-avoidance ability.

2′-Deoxyinosine is a nucleoside form of hypoxanthine. It is a DNA damage product resulting from the impairment of DNA by reactive nitrogen species. 2′-deoxyinosine is formed from nitrosative deamination by N₂O₃.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Gloves, type N95 (US)