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C8031

N6-Cyclopentyladenosine

solid

Sinonimo/i:

CPA

Autenticati per visualizzare i prezzi organizzativi e contrattuali.

Informazioni su questo articolo

Formula empirica (notazione di Hill):
C15H21N5O4
Numero CAS:
41552-82-3
Peso molecolare:
335.36
NACRES:
NA.77
PubChem Substance ID:
24277686
UNSPSC Code:
12352200
MDL number:
MFCD00036845
Form:
solid
Quality level:
200

form

solid

Quality Level

200

color

white to off-white

solubility

H2O: 1.7 mg/mL, 0.1 M HCl: 12 mg/mL, DMSO: 23 mg/mL

storage temp.

2-8°C

SMILES string

OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n2cnc3c(NC4CCCC4)ncnc23

InChI

1S/C15H21N5O4/c21-5-9-11(22)12(23)15(24-9)20-7-18-10-13(16-6-17-14(10)20)19-8-3-1-2-4-8/h6-9,11-12,15,21-23H,1-5H2,(H,16,17,19)/t9-,11-,12-,15-/m1/s1

InChI key

SQMWSBKSHWARHU-SDBHATRESA-N

Gene Information

human ... ADORA1(134), ADORA2A(135), ADORA3(140)
mouse ... Adora1(11539)
rat ... Adora1(29290), Adora2a(25369), Adora3(25370)

Application

N6-Cyclopentyladenosine has also been used to study its effect on p53 and caspase 3, 8, and 9 expression and apoptosis rate in MCF-7 breast cancer cell line.[1]
N6-Cyclopentyladenosine has been used to study its effect on the cavernosal smooth muscle cells from lean and db/db (obesity and type II diabetes caused by a leptin receptor mutation) mice.[2]

Biochem/physiol Actions

N6-Cyclopentyladenosine (CPA) is an adenosine derivative and a potent A1 adenosine receptor agonist.[2] It acts as an anticonvulsant and might exhibit protective actions against aminophylline (AMPH)-induced seizures.
N6-Cyclopentyladenosine also exhibits analgesic effect against acute, arthritis-induced and neuropathic pain.[3]

Features and Benefits

This compound is featured on the Adenosine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Physical form

hygroscopic solid

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Questo articolo
A6563C7938R108
N6-Cyclopentyladenosine solid

Sigma-Aldrich

C8031

N6-Cyclopentyladenosine

6-Anilinoquinoline-5,8-quinone ≥95% (TLC), solid

Sigma-Aldrich

A6563

6-Anilinoquinoline-5,8-quinone

2-Chloro-N6-cyclopentyladenosine adenosine receptor agonist

Sigma-Aldrich

C7938

2-Chloro-N6-cyclopentyladenosine

Ro 41-0960 solid

Sigma-Aldrich

R108

Ro 41-0960

form

solid

form

solid

form

powder

form

solid

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

H2O: 1.7 mg/mL, DMSO: 23 mg/mL, 0.1 M HCl: 12 mg/mL

solubility

0.1 M HCl: 1 mg/mL, methanol: 11 mg/mL, ethanol: 8 mg/mL

solubility

methanol: 19.60-20.40 mg/mL, clear, colorless to faintly yellow

solubility

H2O: slightly soluble <0.7 mg/mL, 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 1.0 mg/mL, ethanol: soluble

color

white to off-white

color

violet

color

-

color

yellow

Gene Information

human ... ADORA1(134), ADORA2A(135), ADORA3(140)
mouse ... Adora1(11539)
rat ... Adora1(29290), Adora2a(25369), Adora3(25370)

Gene Information

-

Gene Information

human ... ADORA1(134), ADORA2A(135), ADORA2B(136), ADORA3(140)
rat ... Adora1(29290), Adora2a(25369), Adora3(25370)

Gene Information

human ... COMT(1312)

Classe di stoccaggio

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificati d'analisi (COA)

Lot/Batch Number
0000113392
038M4058V
105M4130V
076M4127V
13141214

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Ainhoa Bilbao et al.
Addiction biology, 24(5), 1008-1018 (2019-06-27)
The co-occurrence of chronic pain and alcohol use disorders (AUDs) involves complex interactions between genetic and neurophysiological aspects, and the research has reported mixed findings when they both co-occur. There is also an indication of a gender-dependent effect; males are
Yahaira Naaldijk et al.
BMC biotechnology, 16(1), 85-85 (2016-12-03)
Preservation of human skin fibroblasts and keratinocytes is essential for the creation of skin tissue banks. For successful cryopreservation of cells, selection of an appropriate cryoprotectant agent (CPA) is imperative. The aim of this study was to identify CPAs that
Claudia Iasillo et al.
Nucleic acids research, 45(17), 10229-10241 (2017-10-04)
Termination of transcription is important for establishing gene punctuation marks. It is also critical for suppressing many of the pervasive transcription events occurring throughout eukaryotic genomes and coupling their RNA products to efficient decay. In human cells, the ARS2 protein
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Numero articolo commerciale globale

SKUGTIN
C8031-100MG04061832081717
C8031-25MG04061832081724

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