This product is not sterile. Stock solutions may be filter sterilized. This material has not been tested for suitability in cell culture. However, this product has been used successfully in cell culture by other researchers. See the link below to review one such example:
https://pmc.ncbi.nlm.nih.gov/articles/PMC2941681/
A6885
Adenosine 3′,5′-cyclic monophosphate sodium salt monohydrate
≥98.0% (HPLC), cyclic-AMP-dependent protein kinase (PKA) activator, powder
Sinonimo/i:
3′,5′-Cyclic AMP sodium salt, cAMP-Na
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Cambia visualizzazione
| Taglio della confezione | SKU | Disponibilità | Prezzo |
|---|---|---|---|
| 25 mg | Per conoscere la disponibilità, visualizza il carrello | CHF 73.90 | |
| 100 mg | Per conoscere la disponibilità, visualizza il carrello | CHF 182.00 | |
| 500 mg | Per conoscere la disponibilità, visualizza il carrello | CHF 227.00 | |
| 1 g | Per conoscere la disponibilità, visualizza il carrello | CHF 371.00 |
Informazioni su questo articolo
Formula empirica (notazione di Hill):
C10H11N5NaO6P · H2O
Numero CAS:
Peso molecolare:
369.20
UNSPSC Code:
41106305
eCl@ss:
32160414
PubChem Substance ID:
NACRES:
NA.77
Beilstein/REAXYS Number:
54612
MDL number:
Assay:
≥98.0% (HPLC)
Form:
powder
Servizio Tecnico
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Permettici di aiutartiNome del prodotto
Adenosine 3′,5′-cyclic monophosphate sodium salt monohydrate, ≥98.0% (HPLC), powder
Quality Segment
assay
≥98.0% (HPLC)
form
powder
color
white
solubility
H2O: 10 mg/mL
storage temp.
−20°C
SMILES string
[Na+].Nc1ncnc2n(cnc12)[C@@H]3O[C@@H]4COP([O-])(=O)O[C@H]4[C@H]3O
InChI
1S/C10H12N5O6P.Na/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7-4(20-10)1-19-22(17,18)21-7;/h2-4,6-7,10,16H,1H2,(H,17,18)(H2,11,12,13);/q;+1/p-1/t4-,6-,7-,10-;/m1./s1
InChI key
BXJBFCKTIWRKMQ-MCDZGGTQSA-M
Application
Adenosine-3′,5′-cyclic monophosphate (cAMP) is an activator of cyclic-AMP-dependent protein kinase A (PKA). The cAMP/PKA signaling pathway has been shown to inhibit cell proliferation, induce differentiation and lead to apoptosis. Exogneous cAMP plays a role in the spontaneous activity and contraction of the heart muscle.
Biochem/physiol Actions
Naturally-occurring activator of cyclic-AMP-dependent protein kinase (PKA).
Naturally-occurring activator of cyclic-AMP-dependent protein kinase (PKA). cAMP is an important second messenger that is linked in many systems to neurotransmitter- or hormone-induced receptor stimulation. The cAMP/PKA signaling pathway has been shown to inhibit cell proliferation, induce differentiation and lead to apoptosis.
Features and Benefits
This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Phosphodiesterases and PKA & PKG pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
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Questo articolo | |||
|---|---|---|---|
| assay ≥98.0% (HPLC) | assay ≥98.5% (HPLC) | assay ≥93% | assay ≥98% (HPLC) |
| form powder | form powder | form powder | form powder |
| Quality Level 200 | Quality Level 200 | Quality Level 200 | Quality Level 100 |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. −20°C |
| solubility H2O: 10 mg/mL | solubility H2O: 10 mg/mL, clear, colorless (pH of aqueous solution is approx. 3.0. The sodium salt (A6885) is about 20× more soluble.) | solubility water: 50 mg/mL, clear, colorless | solubility - |
| color white | color white | color - | color white to beige |
Classe di stoccaggio
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Articoli
Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.
Numero articolo commerciale globale
| SKU | GTIN |
|---|---|
| A6885-1G | 04061833383001 |
| A6885-500MG | 04061833383025 |
| A6885-25MG | 04061833383018 |
| A6885-100MG | 04061833382998 |
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Is this product sterile? Can be used in cell culture?
1 answer-
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