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S9192

Sigma-Aldrich

Ser-Leu-Ile-Gly-Lys-Val-amide

≥95% (HPLC), solid

Sinonimo/i:

PAR-2 (1-6) Human, PAR2 activating peptide, PAR2-AP, SLIGKV-NH2

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CHF 54.50

About This Item

Formula empirica (notazione di Hill):
C28H54N8O7
Numero CAS:
190383-13-2
Peso molecolare:
614.78
Numero MDL:
MFCD02259590
Codice UNSPSC:
12352200
ID PubChem:
329824618
NACRES:
NA.32

CHF 54.50

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Livello qualitativo

200

Saggio

≥95% (HPLC)

Stato

solid

N° accesso UniProt

Q9WTL4

Temperatura di conservazione

−20°C

Stringa SMILE

CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CO)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(N)=O

InChI

1S/C28H54N8O7/c1-7-17(6)23(36-27(42)20(12-15(2)3)34-25(40)18(30)14-37)28(43)32-13-21(38)33-19(10-8-9-11-29)26(41)35-22(16(4)5)24(31)39/h15-20,22-23,37H,7-14,29-30H2,1-6H3,(H2,31,39)(H,32,43)(H,33,38)(H,34,40)(H,35,41)(H,36,42)/t17-,18-,19-,20-,22-,23-/m0/s1
HOWDUIVVWDUEED-WAUHAFJUSA-N

Informazioni sul gene

mouse ... Insrr(23920)

Amino Acid Sequence

Ser-Leu-Ile-Gly-Lys-Val-NH2

Azioni biochim/fisiol

Proteinase-activated receptor (PAR-2) is a member of proteolytically cleaved receptors. It is activated by a synthetic peptide (SLIGKV), that is exposed after trypsin cleavage of the amino terminus.[1] PAR-2 stimulates an increase in cytosolic Ca2+ ion concentration.[2]
Proteinase-activated receptor-2 (PAR2)-activating peptide.

Confezionamento

Bottomless glass bottle. Contents are inside inserted fused cone.

Altre note

Lyophilized from 0.1% TFA in H2O

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

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Certificati d'analisi (COA)

Lot/Batch Number
0000348607
0000348607
0000226590
099M4857V

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D Quanjun et al.
European review for medical and pharmacological sciences, 20(22), 4688-4696 (2016-12-03)
Esophageal Cancer (EC) is a common malignant tumor occurred in the digestive tract. In this study, we investigated the mechanism of Protease Activated Receptor 2 (PAR-2) on the proliferation of esophageal cancer cell. Transfected esophageal cancer (EC) cell (PAR-2shRNA EC109)
Kaushik Das et al.
Scientific reports, 8(1), 7357-7357 (2018-05-11)
Metastasis, the hallmark of cancer propagation is attributed by the modification of phenotypic/functional behavior of cells to break attachment and migrate to distant body parts. Cancer cell-secreted microvesicles (MVs) contribute immensely in disease propagation. These nano-vesicles, generated from plasma membrane
Hendrik Ungefroren et al.
Molecular pharmacology, 92(5), 519-532 (2017-08-27)
Transforming growth factor-
Abhishek Roy et al.
The Journal of biological chemistry, 292(33), 13688-13701 (2017-05-20)
Cell migration and invasion are very characteristic features of cancer cells that promote metastasis, which is one of the most common causes of mortality among cancer patients. Emerging evidence has shown that coagulation factors can directly mediate cancer-associated complications either
Kenjiro Kaji et al.
Veterinary pathology, 58(1), 53-62 (2020-10-16)
Protease-activated receptor-2 (PAR2) is a G protein-coupled receptor that is activated by serine proteases. In humans, PAR2 is highly expressed in various cancers, including breast cancer, and is associated with cancer progression and metastasis. However, the expression and roles of
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