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S2812

Sigma-Aldrich

SNC80

≥98% (HPLC), solid

Sinonimo/i:

(+)-4-[(αR)-α-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N,N-diethylbenzamide, SNC 80, SNC-80

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About This Item

Formula empirica (notazione di Hill):
C28H39N3O2
Numero CAS:
156727-74-1
Peso molecolare:
449.63
Numero MDL:
MFCD00672673
Codice UNSPSC:
12352200
ID PubChem:
24278698
NACRES:
NA.77

Saggio

≥98% (HPLC)

Forma fisica

solid

Colore

off-white

Solubilità

DMSO: soluble

Stringa SMILE

CCN(CC)C(=O)c1ccc(cc1)[C@H](N2C[C@H](C)N(CC=C)C[C@H]2C)c3cccc(OC)c3

InChI

1S/C28H39N3O2/c1-7-17-30-19-22(5)31(20-21(30)4)27(25-11-10-12-26(18-25)33-6)23-13-15-24(16-14-23)28(32)29(8-2)9-3/h7,10-16,18,21-22,27H,1,8-9,17,19-20H2,2-6H3/t21-,22+,27?/m0/s1
KQWVAUSXZDRQPZ-QNWUEUMSSA-N

Informazioni sul gene

human ... OPRD1(4985)
mouse ... Oprd1(18386)
rat ... Oprd1(24613) , Oprm1(25601)

Applicazioni

Rats were administered SNC80 to study the role of nitric oxide synthase in peripheral antinociception mechanism.5

Azioni biochim/fisiol

SNC80 is a highly selective agonist of δ opioid receptor but also binds to μ-δ opioid receptor heteromers to produce antinociception in mice.2 It also acts as anti-depressant3, elicits dopamine-related behaviors and enhances behavioral responses to psychostimulants.4
SNC80 is a δ opioid receptor agonist.

Caratteristiche e vantaggi

This compound is featured on the Opioid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

Certificati d'analisi (COA)

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Paul Chu Sin Chung et al.
Behavioural brain research, 278, 429-434 (2014-12-03)
The delta opioid receptor (DOR) has raised much interest for the development of new therapeutic drugs, particularly to treat patients suffering from mood disorders and chronic pain. Unfortunately, the prototypal DOR agonist SNC80 induces mild epileptic seizures in rodents. Although
Iness Charfi et al.
Cellular and molecular life sciences : CMLS, 71(8), 1529-1546 (2013-09-12)
Signaling bias refers to G protein-coupled receptor ligand ability to preferentially activate one type of signal over another. Bias to evoke signaling as opposed to sequestration has been proposed as a predictor of opioid ligand potential for generating tolerance. Here
Richard M van Rijn et al.
The Journal of pharmacology and experimental therapeutics, 344(1), 179-188 (2012-10-26)
Drugs targeting G-protein-coupled receptors (GPCRs) make up more than 25% of all prescribed medicines. The ability of GPCRs to form heteromers with unique signaling properties suggests an entirely new and unexplored pool of drug targets. However, current in vitro assays
Laura S Moye et al.
Cephalalgia : an international journal of headache, 39(1), 77-90 (2018-05-18)
Post-traumatic headache is the most common and long-lasting impairment observed following mild traumatic brain injury, and frequently has migraine-like characteristics. The mechanisms underlying progression from mild traumatic brain injury to post-traumatic headache are not fully understood. The aim of this
Akiyoshi Saitoh et al.
Behavioural brain research, 223(2), 271-279 (2011-05-14)
We previously reported that the δ opioid receptor (DOP) agonists SNC80 and TAN-67 produce potent antidepressant-like and antinociceptive effects in rodents. However, SNC80 produced convulsive effects. Recently, we succeeded in synthesizing a novel DOP agonist called KNT-127. The present study
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