Passa al contenuto
Merck

Documenti fondamentali

Visualizza tutta la documentazione

Vai a

P3371

Penfluridol

≥97% (HPLC), powder

Sinonimo/i:

1-[4,4-Bis(4-fluorophenyl)butyl]-4-[4-chloro-3(trifluoromethyl)phenyl]-4-piperidinol, R16341

Autenticati per visualizzare i prezzi organizzativi e contrattuali.

Scegli un formato

Cambia visualizzazione
Taglio della confezioneSKUDisponibilitàPrezzo
50 mg
Per conoscere la disponibilità, visualizza il carrello
CHF 158.00
CHF 134.30

Informazioni su questo articolo

Formula empirica (notazione di Hill):
C28H27ClF5NO
Numero CAS:
26864-56-2
Peso molecolare:
523.97
NACRES:
NA.77
PubChem Substance ID:
329820171
UNSPSC Code:
12352200
EC Number:
248-074-5
MDL number:
MFCD00866714
Assay:
≥97% (HPLC)
Form:
powder
Quality level:
100

CHF 134.30

Prezzo di listinoCHF 158.00Risparmia il 15%
Promozione valida solo online
Per conoscere la disponibilità, visualizza il carrello
​
Richiedi un ordine in blocco
Servizio Tecnico
Hai bisogno di aiuto? Il nostro team di scienziati qualificati è a tua disposizione.
Permettici di aiutarti

Quality Level

100

assay

≥97% (HPLC)

form

powder

color

white

solubility

DMSO: >20 mg/mL, H2O: insoluble

originator

Johnson & Johnson

storage temp.

2-8°C

SMILES string

OC1(CCN(CCCC(c2ccc(F)cc2)c3ccc(F)cc3)CC1)c4ccc(Cl)c(c4)C(F)(F)F

InChI

1S/C28H27ClF5NO/c29-26-12-7-21(18-25(26)28(32,33)34)27(36)13-16-35(17-14-27)15-1-2-24(19-3-8-22(30)9-4-19)20-5-10-23(31)11-6-20/h3-12,18,24,36H,1-2,13-17H2

InChI key

MDLAAYDRRZXJIF-UHFFFAOYSA-N

Application

Penfluridol has been used as an antipsychotic agent:
  • to study its antimetastatic effect on triple-negative breast cancer cells[1]
  • to study its effects on the growth of glioblastoma cell lines[1],
  • to study its effects on the vascular endothelial growth factor (VEGF)-induced angiogenesis in human umbilical vein endothelial cells (HUVECs)[2]

Biochem/physiol Actions

Penfluridol is studied in the treatment of schizophrenia, Tourette syndrome and acute psychosis.[2] It also exhibits anticancer activity.[1]
T-type Ca2+ channel blocker; antipsychotic

Features and Benefits

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Confronta articoli simili

Visualizza il confronto per intero

Mostra le differenze

1 of 1

Questo articolo
SML1809P1793SML1241
Penfluridol ≥97% (HPLC), powder

Sigma-Aldrich

P3371

Penfluridol

PPTN trifluoroacetate salt ≥98% (HPLC)

Sigma-Aldrich

SML1809

PPTN trifluoroacetate salt

Pimozide

Sigma-Aldrich

P1793

Pimozide

Pyr6 ≥98% (HPLC)

Sigma-Aldrich

SML1241

Pyr6

form

powder

form

powder

form

powder

form

powder

assay

≥97% (HPLC)

assay

≥98% (HPLC)

assay

-

assay

≥98% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

200

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: >20 mg/mL, H2O: insoluble

solubility

DMSO: 10 mg/mL, clear

solubility

DMSO: 18 mg/mL(lit.), chloroform: 5 mg/mL, H2O: insoluble(lit.)

solubility

DMSO: 20 mg/mL, clear

color

white

color

white to beige

color

-

color

white to beige

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301

Hazard Classifications

Acute Tox. 3 Oral

Classe di stoccaggio

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Scegli una delle versioni più recenti:

Certificati d'analisi (COA)

Lot/Batch Number
0000398879
0000398879
0000390430
0000390430
0000166335

Non trovi la versione di tuo interesse?

Se hai bisogno di una versione specifica, puoi cercare il certificato tramite il numero di lotto.

Cerca un COA

Possiedi già questo prodotto?

I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.

Visita l’Archivio dei documenti

J J Enyeart et al.
Molecular endocrinology (Baltimore, Md.), 7(8), 1031-1040 (1993-08-01)
The function of low voltage-activated T-type Ca2+ channels in ACTH-stimulated cortisol production by bovine adrenal zona fasciculata cells (AZF) was explored in patch clamp and secretion studies. Nearly all AZF cells expressed only a low voltage-activated T-type Ca2+ current (IT)
J G Won et al.
Endocrinology, 126(2), 858-868 (1990-02-01)
We examined the effects of removing extracellular Ca2+ (Ca2+e), depleting intracellular Ca2+ (Ca2+i), inhibiting cAMP-dependent calmodulin, and blocking voltage-sensitive Ca2+ channels on the secretion of ACTH by perifused dispersed rat anterior pituitary cells. The cells were stimulated with synthetic arginine
Orna Diav-Citrin et al.
The Journal of clinical psychiatry, 66(3), 317-322 (2005-03-16)
To assess the safety of the butyrophenone neuroleptics haloperidol and penfluridol in pregnancy. The rate of major anomalies was compared between a cohort of pregnant women counseled for gestational exposure to haloperidol or penfluridol and a control group counseled for
Visualizza tutti i documenti correlati

Numero articolo commerciale globale

SKUGTIN
P3371-50MG04061834367765

Questions

Reviews

No rating value

Active Filters