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P0077

Prostratin

≥98% (HPLC), PKC activator, powder

Sinonimo/i:

12-Deoxyphorbol-13-acetate, CCRIS 6292, NSC 623310

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Cambia visualizzazione
Taglio della confezioneSKUDisponibilitàPrezzo
1 mg
Per conoscere la disponibilità, visualizza il carrello
CHF 118.00
5 mg
Per conoscere la disponibilità, visualizza il carrello
CHF 481.00

Informazioni su questo articolo

Formula empirica (notazione di Hill):
C22H30O6
Numero CAS:
60857-08-1
Peso molecolare:
390.47
UNSPSC Code:
12352200
PubChem Substance ID:
329820006
NACRES:
NA.77
MDL number:
MFCD00674138
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
100

CHF 118.00

Per conoscere la disponibilità, visualizza il carrello
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Nome del prodotto

Prostratin, ≥98% (HPLC)

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white

solubility

DMSO: 10 mg/mL, clear

storage temp.

−20°C

SMILES string

C[C@@H]1C[C@]2(OC(C)=O)[C@H]([C@@H]3C=C(CO)C[C@@]4(O)[C@@H](C=C(C)C4=O)[C@@]13O)C2(C)C

InChI

1S/C22H30O6/c1-11-6-16-20(26,18(11)25)9-14(10-23)7-15-17-19(4,5)21(17,28-13(3)24)8-12(2)22(15,16)27/h6-7,12,15-17,23,26-27H,8-10H2,1-5H3/t12-,15+,16-,17-,20-,21+,22-/m1/s1

InChI key

BOJKFRKNLSCGHY-HXGSDTCMSA-N

Application

Prostratin has been used to reverse the latency of human immunodeficiency virus-1 (HIV-1) and to quantify the transcriptional activation of the long terminal repeat (LTR) in latently HIV-1-infected Jurkat (J-Lat) cell lines.

Biochem/physiol Actions

Prostratin, an unusual non-tumorigenic phorbol ester, is an activator of protein kinase C (PKC) and also an activator of nuclear factor KB (NF-KB) mediated through activation of the IKKs (IKB kinases).
Prostratin, an unusual non-tumorigenic phorbol ester, is an activator of protein kinase C (PKC) and also an activator of nuclear factor KB (NF-KB) mediated through activation of the IKKs (IKB kinases). Prostratin exhibits potent in vitro activity by inducing HIV expression in latently infected cell lines and primary cells, thus antagonizing HIV latency. Activation of PKC and NF-kB has been proposed as the mechanism of action. Prostratin also inhibits HIV entry into target cells by down-regulating CD4 and CXCR4 receptors.

Features and Benefits

This compound is featured on the PKC page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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Questo articolo
SML1897P8014O9890
Prostratin ≥98% (HPLC)

Sigma-Aldrich

P0077

Prostratin

NSC73306 ≥98% (HPLC)

Sigma-Aldrich

SML1897

NSC73306

4α-Phorbol 12,13-didecanoate solid

Sigma-Aldrich

P8014

4α-Phorbol 12,13-didecanoate

5Z-7-Oxozeaenol ≥98% (HPLC)

Sigma-Aldrich

O9890

5Z-7-Oxozeaenol

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

-

assay

≥98% (HPLC)

form

powder

form

powder

form

solid

form

powder

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

2-8°C

solubility

DMSO: 10 mg/mL, clear

solubility

DMSO: 10 mg/mL, clear

solubility

DMSO: soluble, ethanol: soluble, methanol: soluble

solubility

DMSO: >10 mg/mL

color

white

color

, yellow to light brown

color

white

color

white to off-white

Classe di stoccaggio

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificati d'analisi (COA)

Lot/Batch Number
0000551154
0000546277
0000534009
0000551154
0000546277

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Articoli

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Protein kinase C (PKC) is an AGC kinase that phosphorylates serine and threonine residues in many target proteins.

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The Journal of biological chemistry, 279(40), 42008-42017 (2004-07-31)
A subset of quiescent memory CD4 T cells harboring integrated but transcriptionally silent proviruses poses a currently insurmountable barrier to the eradication of the human immunodeficiency virus (HIV) in infected patients. Induction of HIV gene expression in these latently infected
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Numero articolo commerciale globale

SKUGTIN
P0077-1MG04061826703557
P0077-5MG04061833220085

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