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P8014

Sigma-Aldrich

4α-Phorbol 12,13-didecanoate

solid

Sinonimo/i:

4α-Phorbol 12-13-dicaprinate, 4αPDD

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About This Item

Formula empirica (notazione di Hill):
C40H64O8
Numero CAS:
27536-56-7
Peso molecolare:
672.93
Beilstein:
2514324
Numero MDL:
MFCD00036737
Codice UNSPSC:
12352211
ID PubChem:
24898900
NACRES:
NA.77

Forma fisica

solid

Livello qualitativo

100

Colore

white

Solubilità

DMSO: soluble
ethanol: soluble
methanol: soluble

Temperatura di conservazione

−20°C

Stringa SMILE

CCCCCCCCCC(=O)O[C@@H]1[C@@H](C)[C@@]2(O)C(C=C(CO)C[C@]3(O)C2C=C(C)C3=O)C4C(C)(C)[C@]14OC(=O)CCCCCCCCC

InChI

1S/C40H64O8/c1-7-9-11-13-15-17-19-21-32(42)47-36-28(4)39(46)30(24-29(26-41)25-38(45)31(39)23-27(3)35(38)44)34-37(5,6)40(34,36)48-33(43)22-20-18-16-14-12-10-8-2/h23-24,28,30-31,34,36,41,45-46H,7-22,25-26H2,1-6H3/t28-,30+,31-,34-,36-,38+,39-,40-/m1/s1
DGOSGFYDFDYMCW-OEFRVDPMSA-N

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Applicazioni

4α-Phorbol 12,13-didecanoate has been used as a transient receptor potential vanilloid 4 (TRPV4) agonist:
  • to study its effects on Madin-Darby canine kidney (MDCK) cells
  • to study its effects on Ca2+ influx in mice fallopian tubal cells
  • to study its effects on hind paw swelling in mice

Azioni biochim/fisiol

4α-Phorbol 12,13-didecanoate is a transient receptor potential vanilloid 4 (TRPV4) agonist. It promotes extracellular calcium influx into the cells.

Avvertenza

Photosensitive

Ricostituzione

Stock solution cannot be made in aqueous media; dissolve in a water-miscible organic solvent before dilution to working concentrations in aqueous media.

Avvertenze

Danger

Classi di pericolo

Acute Tox. 1 Dermal - Acute Tox. 1 Inhalation - Acute Tox. 2 Oral - Carc. 2 - Resp. Sens. 1 - Skin Corr. 1B - Skin Sens. 1

Codice della classe di stoccaggio

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Certificati d'analisi (COA)

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