M8377

α-Methyl-DL-tryptophan

≥98% (TLC), suitable for cell culture

• Sinonimo/i: α-methyl-tryptophan
• Formula empirica (notazione di Hill): C₁₂H₁₄N₂O₂
• Numero CAS: 153-91-3
• Peso molecolare: 218.25
• UNSPSC Code: 12352209
• PubChem Substance ID: 24897245
• NACRES: NA.26
• MDL number: MFCD00038416

Proprietà

• Nome del prodotto: α-Methyl-DL-tryptophan, crystalline
• assay: ≥98% (TLC)
• Quality Segment: 200
• form: crystalline
• technique(s): tissue culture: suitable
• color: light yellow
• storage temp.: 2-8°C
• SMILES string: CC(N)(Cc1c[nH]c2ccccc12)C(O)=O
• InChI: 1S/C12H14N2O2/c1-12(13,11(15)16)6-8-7-14-10-5-3-2-4-9(8)10/h2-5,7,14H,6,13H2,1H3,(H,15,16)
• InChI key: ZTTWHZHBPDYSQB-UHFFFAOYSA-N

Descrizione

Application

• Nanoengineered sonosensitive platelets for synergistically augmented sonodynamic tumor therapy by glutamine deprivation and cascading thrombosis.: This study explores the use of a-Methyl-DL-tryptophan in enhancing sonodynamic tumor therapy through the deprivation of glutamine and inducing thrombosis, offering a new approach to cancer treatment (Zhou et al., 2023).


• Transporter targeted gatifloxacin prodrugs: synthesis, permeability, and topical ocular delivery.: This article describes the application of a-Methyl-DL-tryptophan in developing transporter-targeted prodrugs, enhancing drug delivery systems, particularly in ocular treatments (Vooturi et al., 2012).


• SLC6A14 (ATB0,+) protein, a highly concentrative and broad specific amino acid transporter, is a novel and effective drug target for treatment of estrogen receptor-positive breast cancer.: The study investigates the role of a-Methyl-DL-tryptophan in targeting SLC6A14 for treating estrogen receptor-positive breast cancer, highlighting its potential as a therapeutic agent (Karunakaran et al., 2011).

Biochem/physiol Actions

α-methyl-DL-tryptophan is a blocker of ATBo, an amino acid transporter whose expression is upregulated in cancer.

Informazioni sulla sicurezza

• Classe di stoccaggio: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)