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M6045

2-Methyl-4-isothiazolin-3-one hydrochloride

≥99%

Sinonimo/i:

MIT hydrochloride, Methylisothiazolinone hydrochloride

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1 g
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CHF 121.00
5 g
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CHF 423.00

Informazioni su questo articolo

Formula empirica (notazione di Hill):
C4H5NOS · HCl
Numero CAS:
Peso molecolare:
151.61
UNSPSC Code:
51102829
NACRES:
NA.76
PubChem Substance ID:
EC Number:
247-499-3
Beilstein/REAXYS Number:
3993054
MDL number:

CHF 121.00


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Quality Segment

biological source

synthetic

assay

≥99%

form

powder

concentration

≤ 100%

technique(s)

cell culture | mammalian: suitable

color

white to beige

mp

165—170 °C ((329 - 338 °F) at ca.990.4 hPa)

solubility

water: soluble 10.0 — 10.4 mg/mL, clear, colorless to faint yellow or tan

suitability

suitable for component for culture media

application(s)

microbiology

mode of action

protein synthesis | interferes

storage temp.

2-8°C

SMILES string

Cl[H].CN1SC=CC1=O

InChI

1S/C4H5NOS.ClH/c1-5-4(6)2-3-7-5;/h2-3H,1H3;1H

InChI key

SJXPQSRCFCPWQQ-UHFFFAOYSA-N

General description

2-Methyl-4-isothiazolin-3-one hydrochloride (MIT HCl) is a derivative of the synthetic isothiazolinone.[1]

Application

Methylisothiazolinone (MIT HCl) has been used:


  • as a cytotoxic substance to investigate its effect on bronchial epithelial cells (BEAS-2B cells) and its role in apoptotic cell death[1]
  • to study the effects of tyrosine phosphorylation on focal adhesion kinase (FAK) activity in the development of neural axons and dendrites

Biochem/physiol Actions

2-Methyl-4-isothiazolin-3-one hydrochloride (MIT HCl) is a skin sensitizer[2] known to cause contact dermatitis and allergy.[3] It is extensively used in the cosmetic industry as a preservative.[4] MIT HCl is a neurotoxin and its prolonged exposure may lead to neuronal death and inhibition of neurite outgrowth.[5][6]

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Questo articolo
725765SBR0003246078
MIT HCl Ready Made Solution, (125-130 mg MIT HCl/mL in water)

Sigma-Aldrich

SBR00032

MIT HCl

mode of action

protein synthesis | interferes

mode of action

-

mode of action

protein synthesis | interferes

mode of action

-

technique(s)

cell culture | mammalian: suitable

technique(s)

-

technique(s)

-

technique(s)

-

Quality Level

200

Quality Level

100

Quality Level

200

Quality Level

100

assay

≥99%

assay

≥94.0% (GC), 95%

assay

-

assay

-

suitability

suitable for component for culture media

suitability

-

suitability

-

suitability

-

application(s)

microbiology

application(s)

-

application(s)

-

application(s)

agriculture
environmental


signalword

Danger

Hazard Classifications

Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Skin Corr. 1A - Skin Sens. 1

supp_hazards

Classe di stoccaggio

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges



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Questions

1–2 of 2 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

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