M5750

Menadione sodium bisulfite

≥95% (TLC)

• Sinonimo/i: 2-Methyl-1,4-naphthoquinone sodium bisulfite
• Formula empirica (notazione di Hill): C₁₁H₉NaO₅S
• Numero CAS: 130-37-0
• Peso molecolare: 276.24
• Numero CE: 204-987-0
• Numero MDL: MFCD00051456
• Codice UNSPSC: 12352200
• ID PubChem: 24897038
• NACRES: NA.77

Proprietà

• Origine biologica: synthetic
• Livello qualitativo: 200
• Saggio: ≥95% (TLC)
• Forma fisica: powder
• Colore: white to off-white
• Solubilità: H₂O: ≥50 mg/mL, clear, colorless to faintly yellow
• applicazioni: cell analysis
• Ideatore: Eli Lilly
• Temperatura di conservazione: −20°C
• Stringa SMILE: [Na+].CC1(CC(=O)c2ccccc2C1=O)S([O-])(=O)=O
• InChI: 1S/C11H10O5S.Na/c1-11(17(14,15)16)6-9(12)7-4-2-3-5-8(7)10(11)13;/h2-5H,6H2,1H3,(H,14,15,16);/q;+1/p-1; XDPFHGWVCTXHDX-UHFFFAOYSA-M

Descrizione

Applicazioni

Menadione sodium bisulfite has been used:

• as a priming agent in tomato for improving salt tolerance
• to induce reactive oxygen species (ROS) in human lung epithelium BEAS-2B microtissues
• to induce endogenous superoxide production in mouse C17.2 neural stem cells

Azioni biochim/fisiol

Menadione sodium bisulfite is a water-soluble form of menadione, which belongs to the Vitamin K class of compounds. These are necessary for the biosynthesis of prothrombin and other blood clotting factors. Menadione is a prothrombogenic compound and is used as a model quinone in cell culture and in vivo investigations.

Menadione has been shown to affect gap-junctional intercellular communication by mediation of tyrosine phosphorylation. Menadione has demonstrated cytotoxic activity against a variety of cell lines and can induce apoptosis in cultured cells, such as osteoclasts and osteoblasts, via elevation of peroxide and superoxide radical levels.

An HPLC method for detection of menadione sodium bisulfite in multivitamin formulations has been published. A chemiluminescence assay for menadione sodium bisulfite in pharmaceutical preparations and biological fluids has been reported.

Caratteristiche e vantaggi

This compound was developed by Eli Lilly. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Altre note

Water soluble vitamin K₃.

Informazioni sulla sicurezza

• Pittogrammi: GHS07,GHS09
• Avvertenze: Warning
• Indicazioni di pericolo: H315,H319,H410
• Consigli di prudenza: P264 - P273 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313
• Classi di pericolo: Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2
• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: dust mask type N95 (US), Eyeshields, Gloves