GS64
GST A4-4, Recombinant Human
Sinonimo/i:
GTA4, glutathione S-transferase alpha 4
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Cambia visualizzazione
| Taglio della confezione | SKU | Disponibilità | Prezzo |
|---|---|---|---|
| 100 μg | Per conoscere la disponibilità, visualizza il carrello | CHF 437.00 |
Informazioni su questo articolo
NACRES:
NA.26
UNSPSC Code:
12352200
Form:
frozen liquid
Assay:
>95% (SDS-PAGE)
Biological source:
human
Recombinant:
expressed in E. coli
Mol wt:
25 kDa
Servizio Tecnico
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Permettici di aiutartibiological source
human
Quality Level
recombinant
expressed in E. coli
assay
>95% (SDS-PAGE)
form
frozen liquid
specific activity
3.68 units/mg protein
mol wt
25 kDa
concentration
1.01 mg/mL
storage temp.
−70°C
Gene Information
human ... GSTA4(2941)
General description
using spectrophotometric determination of 1-chloro-2,4-dinitrobenzene (CDNB) conjugation with reduced glutathione (1 mM) in 100 mM NaPO4 (pH 6.5) at room temperature.
Biochem/physiol Actions
Glutathione S-transferase alpha 4 (GSTA4) is an enzyme that in humans is encoded by the GSTA4 gene. Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. Based on their biochemical, immunologic, and structural properties, cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. The GSTs are thought to function in xenobiotic metabolism and play a role in susceptibility to cancer, and other diseases.
This gene encodes a glutathione S-tranferase belonging to the alpha class. The alpha class genes, which are located in a cluster on chromosome 6, are highly related and encode enzymes with glutathione peroxidase activity that function in the detoxification of lipid peroxidation products. Reactive electrophiles produced by oxidative metabolism have been linked to a number of degenerative diseases including Parkinson′s disease, Alzheimer′s disease, cataract formation, and atherosclerosis.
Preparation Note
The enzyme should be used by the end-user customer within 1 year of receipt.
1 of 1
Questo articolo | |||
|---|---|---|---|
| biological source human | biological source human | biological source human | biological source bovine |
| recombinant expressed in E. coli | recombinant expressed in E. coli | recombinant expressed in E. coli | recombinant expressed in E. coli |
| assay >95% (SDS-PAGE) | assay >95% (SDS-PAGE) | assay >95% (SDS-PAGE) | assay >95% (SDS-PAGE) |
| concentration 1.01 mg/mL | concentration 2.0 mg/mL | concentration 2.55 mg/mL | concentration 1.42 mg/mL |
| form frozen liquid | form frozen liquid | form frozen liquid | form frozen liquid |
| mol wt 25 kDa | mol wt 23 kDa | mol wt 26 kDa | mol wt 23 kDa |
Classe di stoccaggio
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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Contenuto correlato
Kaname Uno et al.
Molecular carcinogenesis, 50(10), 781-790 (2011-07-14)
Oxidative stress might participate in the carcinogenesis of human esophageal squamous cell carcinomas (hESCC). 4-Hydroxynonenal (HNE) is a major product of membrane lipid peroxidation with short life. It might act as an important mediator through the generation of adducts and
Ji Qian et al.
Molecular carcinogenesis, 48(3), 253-259 (2008-09-04)
GST Alpha 4 (GSTA4) has an important role in the protection against oxidative stress induced by carcinogens such as tobacco smoke. However, few studies investigated the association between GSTA4 polymorphisms and lung cancer risk. We genotyped three selected GSTA4 SNPs
Fabio Coppedè et al.
Mutation research, 579(1-2), 107-114 (2005-08-02)
Several lines of evidence, including an increased level of lipid peroxidation and the depletion of antioxidant molecules like as glutathione (GSH), indicate that oxidative stress plays an important role in the pathogenesis of several neurodegenerative disorders, such as Parkinson's disease
Numero articolo commerciale globale
| SKU | GTIN |
|---|---|
| GS64-100UG | 04061833655467 |