G9893

Gliotoxin

from Gliocladium fimbriatum, ≥98% (HPLC), powder, immunomodulating agent

• Sinonimo/i: Aspergillin
• Formula empirica (notazione di Hill): C₁₃H₁₄N₂O₄S₂
• Numero CAS: 67-99-2
• Peso molecolare: 326.39
• UNSPSC Code: 12352200
• PubChem Substance ID: 24895384
• NACRES: NA.77
• Beilstein/REAXYS Number: 50675
• MDL number: MFCD00058534
• Quality level: 200

Proprietà

• Nome del prodotto: Gliotoxin from Gliocladium fimbriatum,
• Quality Level: 200
• antibiotic activity spectrum: viruses
• mode of action: DNA synthesis | interferes, enzyme | inhibits
• storage temp.: 2-8°C
• SMILES string: CN1C(=O)[C@]23CC4=CC=C[C@H](O)[C@H]4N2C(=O)[C@@]1(CO)SS3
• InChI: 1S/C13H14N2O4S2/c1-14-10(18)12-5-7-3-2-4-8(17)9(7)15(12)11(19)13(14,6-16)21-20-12/h2-4,8-9,16-17H,5-6H2,1H3/t8-,9-,12+,13+/m0/s1
• InChI key: FIVPIPIDMRVLAY-RBJBARPLSA-N

Descrizione

General description

Gliotoxin is the mycotoxin produced by Aspergillus fumigatus (AF). It is a hydrophobic metabolite of 326 Da.

Chemical structure: epipolythiodioxopiperazine

Application

Gliotoxin has been used for performing cytotoxicity tests in adenocarcinomic human alveolar basal epithelial (A549) cell lines.

Noncompetitive inhibitor of the chymotrypsin-like activity of the 20S proteasome in vitro.

Biochem/physiol Actions

Gliotoxin is associated with immunosuppression. It is an antiphagocytic and immunomodulating agent that acts by blocking membrane thiol groups. It is implicated in the pathophysiology of invasive aspergillosis (IA) and impacts functional T-cell responses. Gliotoxin in observed in the sera of cancer patients with IA infection.

Informazioni sulla sicurezza

• pictograms: GHS06
• signalword: Danger
• hcodes: H301
• pcodes: P301 + P310
• Hazard Classifications: Acute Tox. 3 Oral
• Classe di stoccaggio: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges