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F8305

FRK (208-end), active, GST tagged human

PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Sinonimo/i:

GTK, PTK5, RAK

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Informazioni su questo articolo

NACRES:
NA.32
UNSPSC Code:
12352204
Specific activity:
847-1147 nmol/min·mg
Assay:
≥70% (SDS-PAGE)
Recombinant:
expressed in baculovirus infected Sf9 cells

recombinant

expressed in baculovirus infected Sf9 cells

Quality Level

200

product line

PRECISIO® Kinase

assay

≥70% (SDS-PAGE)

form

buffered aqueous glycerol solution

specific activity

847-1147 nmol/min·mg

mol wt

~60 kDa

UniProt accession no.

P42685

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... FRK(2444)

General description

FRK (fyn-related kinase) is a tyrosine kinase, with a molecular weight of 54kDa. It contains SH2 and SH3 (src homology) domains. It is predominantly expressed in tissues of epithelial origin such as, liver, kidney, breast and colon. Its SH2 domain contains a putative bipartite nuclear localization signal.[1]

Biochem/physiol Actions

FRK (fyn-related kinase) controls growth by phosphorylating perinuclear proteins. It inhibits cell growth both in a pRb (retinoblastoma)-dependent and independent manner. It cause cell cycle arrest at G1 phase in breast cancer cells.[2] Certain mutations in this gene lead to its constitutive activation, as seen in hepatocellular adenomas.[3] Its up-regulation in gliomas prevents both invasiveness and migration of glioma cells. This is attributable to its promotion of N-cadherin/β-catenin complex formation.[4]

Physical form

Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.

Legal Information

PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany

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Questo articolo
SAB1405829F7930F6432
FRK (208-end), active, GST tagged human PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Sigma-Aldrich

F8305

FRK (208-end), active, GST tagged human

Anti-FRK antibody produced in mouse purified immunoglobulin, buffered aqueous solution

Sigma-Aldrich

SAB1405829

Anti-FRK antibody produced in mouse

FGFR3 (397-end), active, GST tagged human PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Sigma-Aldrich

F7930

FGFR3 (397-end), active, GST tagged human

FLT3 (571-993), active, GST tagged human PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Sigma-Aldrich

F6432

FLT3 (571-993), active, GST tagged human

assay

≥70% (SDS-PAGE)

assay

-

assay

≥70% (SDS-PAGE)

assay

≥70% (SDS-PAGE)

Gene Information

human ... FRK(2444)

Gene Information

human ... FRK(2444)

Gene Information

human ... FGFR3(2261)

Gene Information

human ... FLT3(2322)

specific activity

847-1147 nmol/min·mg

specific activity

-

specific activity

95-129 nmol/min·mg

specific activity

60-81 nmol/min·mg

form

buffered aqueous glycerol solution

form

buffered aqueous solution

form

buffered aqueous glycerol solution

form

buffered aqueous glycerol solution

recombinant

expressed in baculovirus infected Sf9 cells

recombinant

-

recombinant

expressed in baculovirus infected Sf9 cells

recombinant

expressed in baculovirus infected Sf9 cells

storage temp.

−70°C

storage temp.

−20°C

storage temp.

−70°C

storage temp.

−70°C

Classe di stoccaggio

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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Certificati d'analisi (COA)

Lot/Batch Number

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Camilla Pilati et al.
Cancer cell, 25(4), 428-441 (2014-04-17)
Hepatocellular adenomas (HCA) are benign liver tumors predominantly developed in women using oral contraceptives. Here, exome sequencing identified recurrent somatic FRK mutations that induce constitutive kinase activity, STAT3 activation, and cell proliferation sensitive to Src inhibitors. We also found uncommon
Qiong Shi et al.
Journal of molecular neuroscience : MN, 55(1), 32-41 (2014-06-28)
Fyn-related kinase (FRK), a member of Src-related tyrosine kinases, is recently reported to function as a potent tumor suppressor in several cancer types. Our previous study has also shown that FRK over-expression inhibited the migration and invasion of glioma cells.
Tanya Meyer et al.
International journal of cancer, 104(2), 139-146 (2003-02-06)
Rak is a 54 kDa protein tyrosine kinase originally isolated from breast cancer cells and expressed in epithelial cells. It resembles the protooncogene Src structurally but lacks an amino-terminal myristylation site and localizes to the nuclear and perinuclear regions of
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Numero articolo commerciale globale

SKUGTIN
F8305-100UG04061833253267
F8305-10UG04061837904974

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