C9124
CK-869
≥98% (HPLC), actin assembly inhibitor, powder
Sinonimo/i:
2-(3-Bromophenyl)-3-(2,4-dimethoxyphenyl)-4-thiazolidinone, CK 869, CK-0157869
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Cambia visualizzazione
| Taglio della confezione | SKU | Disponibilità | Prezzo |
|---|---|---|---|
| 5 mg | Per conoscere la disponibilità, visualizza il carrello | CHF 145.00 | |
| 25 mg | Per conoscere la disponibilità, visualizza il carrello | CHF 376.00 CHF 319.60 |
Informazioni su questo articolo
Formula empirica (notazione di Hill):
C17H16BrNO3S
Numero CAS:
Peso molecolare:
394.28
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
Servizio Tecnico
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Permettici di aiutartiNome del prodotto
CK-869, ≥98% (HPLC)
Quality Level
assay
≥98% (HPLC)
form
powder
color
white to light gray
solubility
DMSO: 10 mg/mL, clear
storage temp.
2-8°C
SMILES string
S1C(N(C(=O)C1)c3c(cc(cc3)OC)OC)c2cc(ccc2)Br
InChI
1S/C17H16BrNO3S/c1-21-13-6-7-14(15(9-13)22-2)19-16(20)10-23-17(19)11-4-3-5-12(18)8-11/h3-9,17H,10H2,1-2H3
InChI key
MVWNPZYLNLATCH-UHFFFAOYSA-N
Application
CK-869 has been used as an Arp2/3 complex inhibitor:
- to treat cultured mammalian cells and study its in vitro and in vivo effects on microtubule assembly[1]
- to induce membrane blebbing in HT1080 fibrosarcoma cells[2]
- to treat KDM3A-null cells and study the relation between actin dynamics and ciliogenesis[3]
Biochem/physiol Actions
CK-0157869 (CK-869) prevents microtubule (MT) assembly, free of Arp2/3 complex.[1]
CK-869 is a cell-permeable inhibitor of actin assembly mediated by the actin-related protein Arp2/3 complex of human and bovine, but not yeast.
CK-869 is a cell-permeable inhibitor of actin assembly mediated by the actin-related protein Arp2/3 complex of human and bovine, but not yeast. The actin-related protein Arp2/3 complex plays a major role in the regulation of the actin cytoskeleton. Apparently the compound binds to the hydrophobic core of Arp3 and alters its conformation.
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Questo articolo | |||
|---|---|---|---|
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) |
| form powder | form powder | form powder | form powder |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
| solubility DMSO: 10 mg/mL, clear | solubility DMSO: ≥25 mg/mL | solubility DMSO: ≥20 mg/mL | solubility DMSO: 20 mg/mL, clear |
| color white to light gray | color white to tan | color peach to light pink | color white to beige |
Classe di stoccaggio
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Yuka Yamagishi et al.
Biochemical and biophysical research communications, 496(3), 834-839 (2018-02-06)
Two types of Arp2/3 complex inhibitors, CK-666/636 and CK-548/869, are commonly used to study Arp2/3 complex-dependent actin assembly both in vitro and in vivo. However, we found that CK-548 and CK-869 directly suppress microtubule (MT) assembly independent of the actin cytoskeleton. Treatment
B J Nolen et al.
Nature, 460(7258), 1031-1034 (2009-08-04)
Polymerization of actin filaments directed by the actin-related protein (Arp)2/3 complex supports many types of cellular movements. However, questions remain regarding the relative contributions of Arp2/3 complex versus other mechanisms of actin filament nucleation to processes such as path finding
Aleksandra S Chikina et al.
The Journal of cell biology, 218(2), 445-454 (2018-12-14)
Membrane blebbing accompanies various cellular processes, including cytokinesis, apoptosis, and cell migration, especially invasive migration of cancer cells. Blebs are extruded by intracellular pressure and are initially cytoskeleton-free, but they subsequently assemble the cytoskeleton, which can drive bleb retraction. Despite
Numero articolo commerciale globale
| SKU | GTIN |
|---|---|
| C9124-25MG | 04061833218266 |
| C9124-5MG | 04061833218273 |