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C4397

Chlorzoxazone

Name: Chlorzoxazone
Brand: SIGMA
Price: 89.5 CHF

Sinonimo/i:

5-Chloro-2(3H)-benzoxazolone, 5-Chloro-2-hydroxybenzoxazole

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Taglio della confezione	SKU	Disponibilità	Prezzo
25 g		Per conoscere la disponibilità, visualizza il carrello	CHF 89.50
100 g		Per conoscere la disponibilità, visualizza il carrello	CHF 282.00 CHF 239.70

Informazioni su questo articolo

Formula empirica (notazione di Hill):

C₇H₄ClNO₂

Numero CAS:

95-25-0

Peso molecolare:

169.57

NACRES:

NA.77

PubChem Substance ID:

24277702

UNSPSC Code:

12352200

EC Number:

202-403-9

MDL number:

MFCD00005717

Assay:

≥98% (TLC)

Form:

powder

CHF 89.50

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Proprietà

assay

≥98% (TLC)

Quality Segment

100

form

powder

color

white to off-white

mp

191-192 °C (lit.)

solubility

DMSO: 50 mg/mL, clear

originator

Johnson & Johnson

storage temp.

room temp

SMILES string

Clc1ccc2OC(=O)Nc2c1

InChI

1S/C7H4ClNO2/c8-4-1-2-6-5(3-4)9-7(10)11-6/h1-3H,(H,9,10)

InChI key

TZFWDZFKRBELIQ-UHFFFAOYSA-N

Gene Information

human ... KCNN4(3783)

Descrizione

Application

Chlorzoxazone may be used:

as a calcium-activated potassium (K_Ca) channel activator in patch-clamp electrophysiology to test its effect on dendritic hyperexcitability[1]
as a substrate for cytochrome P450 2E1 (CYP2E1) enzyme in cultured human hepatocytes[2]
as a benzimidazolone compound to test its effect on epithelial sodium (Na⁺) transport[3]

Biochem/physiol Actions

Chlorzoxazone inhibits the multisynaptic reflex arcs primarily in the spinal cord and brain subcortical areas.[4] It is an activator of calcium activated potassium channels and may contribute to the aortic artery relaxation in mice.[5] Chlorzoxazone also activates the calcium-activated potassium (K_Ca) channel and small conductance calcium-activated potassium channels (SK).[1] It is metabolized by cytochrome P450 2E1 (CYP2E1) and serves as a probe for monitoring this enzyme function.[6]

Chlorzoxazone is a skeletal muscle relaxant.

Features and Benefits

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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Questo articolo	UC148	SML1616	SML0866
Sigma-Aldrich C4397 Chlorzoxazone	Sigma-Aldrich UC148 6-Hydroxychlorzoxazone	Sigma-Aldrich SML1616 ICA-069673	Sigma-Aldrich SML0866 BMS-191011
assay ≥98% (TLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)
form powder	form solid	form powder	form powder
Quality Level 100	Quality Level 200	Quality Level 100	Quality Level 100
storage temp. room temp	storage temp. 2-8°C	storage temp. room temp	storage temp. room temp
solubility DMSO: 50 mg/mL, clear	solubility methanol: soluble	solubility DMSO: 20 mg/mL, clear	solubility DMSO: 20 mg/mL, clear (warmed)
originator Johnson & Johnson	originator -	originator -	originator -