Passa al contenuto
Merck

Documenti fondamentali

Visualizza tutta la documentazione

Vai a

B2292

O6-Benzylguanine

≥98% (TLC), solid, O⁶-alkylguanine DNA alkyltransferase inhiitor

Autenticati per visualizzare i prezzi organizzativi e contrattuali.

Scegli un formato

Cambia visualizzazione
A voi/SKUDisponibilitàPrezzo
50 mg

Disponibile per la spedizione OGGIdaSchnelldorf

CHF 100.00

Informazioni su questo articolo

Formula empirica (notazione di Hill):
C12H11N5O
Numero CAS:
19916-73-5
Peso molecolare:
241.25
UNSPSC Code:
12352200
PubChem Substance ID:
24278259
NACRES:
NA.77
MDL number:
MFCD00269931
Assay:
≥98% (TLC)
Form:
solid

CHF 100.00

Disponibile per la spedizione OGGIDettagli

​
Richiedi un ordine in blocco
Servizio Tecnico
Hai bisogno di aiuto? Il nostro team di scienziati qualificati è a tua disposizione.
Permettici di aiutarti

Nome del prodotto

O6-Benzylguanine, ≥98% (TLC), solid

Quality Segment

200

assay

≥98% (TLC)

form

solid

solubility

methanol: 20 mg/mL

storage temp.

room temp

SMILES string

Nc1nc(OCc2ccccc2)c3nc[nH]c3n1

InChI

1S/C12H11N5O/c13-12-16-10-9(14-7-15-10)11(17-12)18-6-8-4-2-1-3-5-8/h1-5,7H,6H2,(H3,13,14,15,16,17)

InChI key

KRWMERLEINMZFT-UHFFFAOYSA-N

Gene Information

human ... MGMT(4255)

Application

O6-Benzylguanine has been used:
  • as an inhibitor of methylguanine methyltransferase (MGMT) in glioblastoma stem cell[1]
  • as a O6-alkylguanine-alkyltransferase (AGT) enzyme inhibitor in embryonic stem cells prior to N-ethyl-N-nitrosourea(ENU) treatment
  • as an inhibitor of AGT in growth inhibition assays of HL-60 human promyelocytic leukemia cells

Biochem/physiol Actions

O(6)-benzylguanine is an antineoplastic agent that binds the DNA repair enzyme O(6)-alkylguanine DNA alkyltransferase (AGT), resulting in inhibition of AGT-mediated DNA repair. It is widely used in various DNA repair mechanism studies and potentiates the effects of other chemotherapeutic agents that damage DNA.
O6-Benzylguanine (O6BG) inhibits methylguanine methyltransferase (MGMT) by blocking the active site through benzyl group transfer.[2] The use of O6BG with bis-chloroethylnitrosourea (BCNU) or carmustine is effective in treating solid tumors including lymphomas, melanomas and sarcoma.[3]

Confronta articoli simili

Visualizza il confronto per intero

Mostra le differenze

1 of 1

Questo articolo
B8279A9657J3770
O6-Benzylguanine ≥98% (TLC), solid

Sigma-Aldrich

B2292

O6-Benzylguanine

4-(3-Butoxy-4-methoxybenzyl)imidazolidin-2-one solid

Sigma-Aldrich

B8279

4-(3-Butoxy-4-methoxybenzyl)imidazolidin-2-one

DL-Aminoglutethimide

Sigma-Aldrich

A9657

DL-Aminoglutethimide

JNJ7777120 ≥98% (HPLC)

Sigma-Aldrich

J3770

JNJ7777120

assay

≥98% (TLC)

assay

≥98% (HPLC)

assay

≥98% (TLC)

assay

≥98% (HPLC)

form

solid

form

solid

form

powder or crystals

form

solid

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

100

storage temp.

room temp

storage temp.

room temp

storage temp.

room temp

storage temp.

room temp

solubility

methanol: 20 mg/mL

solubility

ethanol: 7 mg/mL, H2O: insoluble

solubility

H2O: slightly soluble 0.2 mg/mL, 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 1.2 mg/mL, 0.1 M HCl: soluble, acetonitrile: soluble, methanol: soluble

solubility

DMSO: >20 mg/mL, H2O: insoluble

Gene Information

human ... MGMT(4255)

Gene Information

human ... LITAF(9516), PDE4B(5142), PRKAR1A(5573), PRKAR1AP(5574), PRKAR1B(5575), PRKAR2A(5576), PRKAR2B(5577)
rat ... Pde4a(25638)

Gene Information

human ... CYP11A1(1583), CYP17A1(1586), CYP19A1(1588)
rat ... Cyp19a1(25147)

Gene Information

-

pictograms

Exclamation mark
GHS07

signalword

Warning

Classe di stoccaggio

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Scegli una delle versioni più recenti:

Certificati d'analisi (COA)

Lot/Batch Number

It looks like we've run into a problem, but you can still download Certificates of Analysis from our Documenti section.

Se ti serve aiuto, non esitare a contattarci Servizio Clienti

Possiedi già questo prodotto?

I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.

Visita l’Archivio dei documenti

Questions

Reviews

No rating value

Active Filters