A9227

ABT-491 hydrochloride

≥98% (HPLC), active platelet-activating factor (PAF) receptor antagonist, solid

• Sinonimo/i: 4-Ethynyl-N,N-dimethyl-3-[3-fluoro-4-[(2-methyl-1H-imidazo-[4,5-c]pyridin-1-yl)methyl]benzoyl]-1H-indole-1-carboxamide hydrochloride, A-137491
• Formula empirica (notazione di Hill): C₂₈H₂₂N₅O₂F · HCl
• Numero CAS: 189689-94-9
• Peso molecolare: 515.97
• UNSPSC Code: 12352200
• PubChem Substance ID: 24724404
• NACRES: NA.77
• MDL number: MFCD00945301
• Assay: ≥98% (HPLC)
• Form: solid
• Quality level: 100
• Storage condition: desiccated

Proprietà

• Nome del prodotto: ABT-491 hydrochloride, ≥98% (HPLC)
• Quality Level: 100
• assay: ≥98% (HPLC)
• form: solid
• storage condition: desiccated
• color: white to beige
• mp: 170-178 °C (lit.)
• solubility: H₂O: freely soluble 22 mg/mL
• originator: Abbott
• storage temp.: 2-8°C
• SMILES string: Cl[H].CN(C)C(=O)n1cc(C(=O)c2ccc(Cn3c(C)nc4cnccc34)c(F)c2)c5c(cccc15)C#C
• InChI: 1S/C28H22FN5O2.ClH/c1-5-18-7-6-8-25-26(18)21(16-34(25)28(36)32(3)4)27(35)19-9-10-20(22(29)13-19)15-33-17(2)31-23-14-30-12-11-24(23)33;/h1,6-14,16H,15H2,2-4H3;1H
• InChI key: AWRGBOKANQBIBM-UHFFFAOYSA-N

Descrizione

Biochem/physiol Actions

Highly potent, selective and orally active platelet-activating factor (PAF) receptor antagonist. K_i = 0.6 nM in human platelets.

Features and Benefits

This compound is featured on the PAF Receptor page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informazioni sulla sicurezza

• Classe di stoccaggio: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)