This product is constructed with a single deletion of Asp from the N-terminus to create a hypoallergenic construct. Structural equivalence to native albumin is confirmed by x-ray crystallography. The Asp deletion eliminates an important antigenic determinant by removing the principal copper and nickel binding site of albumin. The first three residues of human albumin are considered non-structural. Additionally, the product is blocked at Cys34 to improve stability, monomer content, and homogeneity.
A7736
Albumina
recombinant, expressed in Pichia pastoris, lyophilized powder, ≥90% (agarose gel electrophoresis)
Sinonimo/i:
rHSA
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Cambia visualizzazione
| Taglio della confezione | SKU | Disponibilità | Prezzo |
|---|---|---|---|
| 1 g | Per conoscere la disponibilità, visualizza il carrello | CHF 203.00 |
Informazioni su questo articolo
Formula empirica (notazione di Hill):
C2936H4624N786O889S41
Numero CAS:
Peso molecolare:
66471.53
UNSPSC Code:
12352202
NACRES:
NA.25
EC Number:
274-272-6
MDL number:
eCl@ss:
42010201
Biological source:
human
Assay:
≥90% (agarose gel electrophoresis)
Form:
lyophilized powder
Technique(s):
cell culture | mammalian: suitable
Servizio Tecnico
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Permettici di aiutartibiological source
human
Quality Level
recombinant
expressed in Pichia pastoris
assay
≥90% (agarose gel electrophoresis)
form
lyophilized powder
mol wt
monomer ~67 kDa
technique(s)
cell culture | mammalian: suitable
UniProt accession no.
storage temp.
2-8°C
SMILES string
FC(F)(F)C(F)(F)C(F)(F)F
InChI
1S/C3F8/c4-1(5,2(6,7)8)3(9,10)11
InChI key
QYSGYZVSCZSLHT-UHFFFAOYSA-N
Gene Information
human ... ALB(213)
General description
Construct with a single deletion of Asp from the N-terminus to create a hypoallergenic construct. Structural equivalence to native albumin confirmed x-ray crystallography. The Asp deletion eliminates an important antigenic determinant by eliminating the principal copper and nickel binding site of albumin. The first three residues of human albumin are considered non-structural. Also blocked at Cys34 to improve stability, monomer content and homogeneity.
Application
Questa variante ricombinante è raccomandata per l'utilizzo nella ricerca farmacologica riguardo a assorbimento, distribuzione, metabolismo ed eliminazione (ADME); per le colture cellulari; per la ricerca sulla somministrazione di farmaci; e per la crioconservazione delle cellule.
Biochem/physiol Actions
Le albumine sono proteine monomeriche solubili presenti nei fluidi corporei, nei tessuti animali e nei semi di alcune piante. L'albumina sierica funziona come proteina carrier per steroidi, acidi grassi e ormoni tiroidei. Le albumine sieriche sono inoltre di vitale importanza nel regolare la pressione colloido-osmotica del sangue.
Other Notes
Visualizzare ulteriori informazioni sull′albumina sierica umana.
Legal Information
Albagen is a trademark of Albumin Therapeutics, LLC.
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Questo articolo | |||
|---|---|---|---|
| assay ≥90% (agarose gel electrophoresis) | assay ≥90% (SDS-PAGE) | assay ≥96% (SDS-PAGE) | assay ≥96% (agarose gel electrophoresis) |
| biological source human | biological source human | biological source human | biological source human |
| technique(s) cell culture | mammalian: suitable | technique(s) cell culture | mammalian: suitable | technique(s) cell culture | mammalian: suitable | technique(s) ELISA: suitable, tissue culture: suitable, western blot: suitable |
| Quality Level 300 | Quality Level 200 | Quality Level 200 | Quality Level 300 |
| form lyophilized powder | form solution | form lyophilized powder | form lyophilized powder |
| Gene Information human ... ALB(213) | Gene Information human ... ALB(213) | Gene Information human ... ALB(213) | Gene Information human ... ALB(213) |
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Classe di stoccaggio
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Numero articolo commerciale globale
| SKU | GTIN |
|---|---|
| A7736-1G | 04061833386248 |
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Hi there, I am looking at the product A7736 recombinant human albumin and I see it is "Albagen™ synonym" according to the description. I know that Albagen has a single deletion N-terminus. So it is not 100% HSA. what about A7736?
1 answer-
Helpful?
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