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85610

Sigma-Aldrich

Spermine tetrahydrochloride

≥99.0% (AT), powder or crystals

Sinonimo/i:

N,N′-Bis(3-aminopropyl)-1,4-butanediamine tetrahydrochloride

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About This Item

Formula empirica (notazione di Hill):
C10H26N4 · 4HCl
Numero CAS:
306-67-2
Peso molecolare:
348.18
Beilstein:
3911771
Numero CE:
206-189-8
Numero MDL:
MFCD00012914
Codice UNSPSC:
12352200
ID PubChem:
329769394
NACRES:
NA.77

Origine biologica

microbial
synthetic

Livello qualitativo

300

Saggio

≥99.0% (AT)

Forma fisica

powder or crystals

Punto di fusione

310-311 °C (dec.) (lit.)

Solubilità

H2O: 0.1 g/mL, clear

Temperatura di conservazione

room temp

Stringa SMILE

Cl.Cl.Cl.Cl.NCCCNCCCCNCCCN

InChI

1S/C10H26N4.4ClH/c11-5-3-9-13-7-1-2-8-14-10-4-6-12;;;;/h13-14H,1-12H2;4*1H
XLDKUDAXZWHPFH-UHFFFAOYSA-N

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Applicazioni

Used to precipitate DNA from low salt aqueous buffers.

Azioni biochim/fisiol

Mixed NMDA agonist/antagonist at the polyamine site. Neuroprotective effects have been observed at high concentrations (1 mM), while neurotoxicity is observed at lower concentrations. It enhances agonist effectiveness at the strychnine-insensitive glycine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).
Mixed NMDA agonist/antagonist at the polyamine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).

Pittogrammi

Exclamation mark
GHS07

Avvertenze

Warning

Indicazioni di pericolo

H315,H319

Classi di pericolo

Eye Irrit. 2 - Skin Irrit. 2

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Gloves

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Anna Czajkowska-Mysłek et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 105, 82-92 (2017-04-04)
Potential adverse reactions among infants and young children could appear after consumption of food containing small amounts of bioactive amines. This study presents the first assessment of biogenic amines occurrence in ready-to-eat vegetable without/with fish, meat and fruit baby products
Desiree Bailey et al.
Pharmacology, biochemistry, and behavior, 133, 57-64 (2015-04-01)
The aim of this study was to examine the acute effect of a range of novel hydroxycinnamic acid derivatives of spermine on the development of spermine-induced CNS excitation and convulsions in female Laca mice, and to assess the chronic adverse
Yong Kee Choi et al.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 19(2), 77-84 (2008-10-11)
Levels of ionotropic glutamate (Glu) N-methyl-d-aspartic acid (NMDA), 2-amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl)propionic acid (AMPA), and kainic acid (KA) receptors in forebrain regions of juvenile rats (age 42 days) were quantified after 3 weeks of treatment with three different doses of risperidone (0.3, 1.0
Enzo Agostinelli et al.
International journal of oncology, 45(3), 1109-1122 (2014-06-28)
It has been confirmed that multidrug resistant (MDR) melanoma cells (M14 ADR2) are more sensitive than their wild-type counterparts (M14 WT) to H2O2 and aldehydes, the products of bovine serum amine oxidase (BSAO)-catalyzed oxidation of spermine. The metabolites formed by
Alexis Goichon et al.
The American journal of clinical nutrition, 102(2), 359-367 (2015-06-26)
Amino acids are well known to be key effectors of gut protein turnover. We recently reported that enteral delivery of proteins markedly stimulated global duodenal protein synthesis in carbohydrate-fed healthy humans, but specifically affected proteins remain unknown. We aimed to
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