345670

Galanthamine, Hydrobromide

A competitive and reversible inhibitor of acetylcholinesterase.

• Sinonimo/i: Galanthamine, Hydrobromide, Nivalin, HBr
• Formula empirica (notazione di Hill): C₁₇H₂₁NO₃ · xHBr
• Numero CAS: 69353-21-5
• Peso molecolare: 287.35 (free base basis)
• MDL number: MFCD05734759
• UNSPSC Code: 12352116
• NACRES: NA.77
• Assay: ≥95% (HPLC)
• Form: solid
• Quality level: 100
• Storage condition: OK to freeze, desiccated

Proprietà

• Quality Level: 100
• description: Merck USA index - 14, 4340
• assay: ≥95% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, desiccated
• color: white
• solubility: ethanol: 1 mg/mL, water: 1 mg/mL, DMSO: 5 mg/mL
• shipped in: ambient
• storage temp.: 2-8°C
• SMILES string: [Br-].[N+H]1(CC[C@@]32[C@@H](Oc4c3c(ccc4OC)C1)C[C@H](C=C2)O)C
• InChI: 1S/C17H21NO3.BrH/c1-18-8-7-17-6-5-12(19)9-14(17)21-16-13(20-2)4-3-11(10-18)15(16)17;/h3-6,12,14,19H,7-10H2,1-2H3;1H/t12-,14-,17-;/m0./s1
• InChI key: QORVDGQLPPAFRS-XPSHAMGMSA-N

Descrizione

General description

A competitive and reversible inhibitor of acetylcholinesterase. Antimyasthenic agent. Can partially reverse the effects of scopolamine-induced amnesia in rats. Reported to improve learning and short-term memory in animal models.

Cholinesterase antagonist. Antimyasthenic agent. Can partially reverse the effects of scopolamine-induced amnesia in rats.

Biochem/physiol Actions

Cell permeable: no

Primary Target
Acetylcholinesterase

Product competes with ATP.

Reversible: yes

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Pilger, C., et al. 2001. J. Mol. Graph. Model19, 288.
Iliev, A., et al. 1999. Methods Find. Exp. Clin. Pharmacol. 21, 297.
Southan, G.J., et al. 1996. Br. J. Pharmacol.117, 619.
Mutafova-Yambolieva, V.N., et al. 1993. Gen. Pharmacol. 24, 1253.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Toxic (F)

Informazioni sulla sicurezza

• pictograms: GHS06
• signalword: Danger
• hcodes: H301
• pcodes: P264 - P270 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 3 Oral
• Classe di stoccaggio: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable