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G1660

Sigma-Aldrich

Galanthamine hydrobromide from Lycoris sp.

≥94% (HPLC)

Sinonimo/i:

Galantamine hydrobromide

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2 MG
CHF 77.20
10 MG
CHF 202.00

CHF 77.20

Spedizione prevista il16 aprile 2025

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2 MG
CHF 77.20
10 MG
CHF 202.00

About This Item

Formula empirica (notazione di Hill):
C17H21NO3 · HBr
Numero CAS:
1953-04-4
Peso molecolare:
368.27
Numero CE:
217-780-5
Numero MDL:
MFCD00067672
Codice UNSPSC:
12352116
ID PubChem:
24895074
NACRES:
NA.32

CHF 77.20

Spedizione prevista il16 aprile 2025

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Origine biologica

plant (Ungeria victoris)

Livello qualitativo

100

Saggio

≥94% (HPLC)

Stato

powder

Punto di fusione

270 °C

Solubilità

DMSO: soluble 10 mg/mL, clear, colorless
water: soluble 20 mg/mL, clear, colorless

Temperatura di conservazione

−20°C

Stringa SMILE

Br[H].COc1ccc2CN(C)CC[C@@]34C=C[C@H](O)C[C@@H]3Oc1c24

InChI

1S/C17H21NO3.BrH/c1-18-8-7-17-6-5-12(19)9-14(17)21-16-13(20-2)4-3-11(10-18)15(16)17;/h3-6,12,14,19H,7-10H2,1-2H3;1H/t12-,14-,17-;/m0./s1
QORVDGQLPPAFRS-XPSHAMGMSA-N

Informazioni sul gene

human ... ACHE(43)

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Descrizione generale

Galanthamine hydrobromide is a derivative of galanthamine, which is an anticholinestrase alkaloid derived from genus Lycoris (Amaryllidaceae) or snowdrop. This compound is used for the treatment of Alzheimer′s disease (AD).[1]

Applicazioni

Galanthamine hydrobromide from Lycoris sp. has been used-
  • as an AChE (acetylcholinesterase) inhibitor and positive control in acetylcholinesterase assay performed to determine the activity of AChE[2]
  • as a positive control in the screening of AChE inhibitors[3]
  • as a positive control in AChE inhibitory assay performed to determine the AChE-inhibitory activities of pyrithione and related sulfur-containing pyridine N-oxides[4]

Azioni biochim/fisiol

Cholinesterase inhibitor; reverses scopolamine-induced amnesia; antimyasthenic.

Confezionamento

Bottomless glass bottle. Contents are inside inserted fused cone.

Pittogrammi

Skull and crossbones
GHS06

Avvertenze

Danger

Indicazioni di pericolo

H301

Consigli di prudenza

P301 + P310

Classi di pericolo

Acute Tox. 3 Oral

Codice della classe di stoccaggio

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

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Certificati d'analisi (COA)

Lot/Batch Number
BCCM5886
BCCH6300
BCCF0790
BCCC1829
BCBX4613

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I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.

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Petra Krejčová et al.
Journal of ethnopharmacology, 154(1), 176-182 (2014-04-12)
Persian shallot (Allium stipitatum) is a bulbous plant native to Turkey, Iran and Central Asia. It is frequently used in folk medicine for the treatment of a variety of disorders, including inflammation and stress. Antiinflammatory and neurological activities of pyrithione
Sony Pandey et al.
Microbial cell factories, 13(1), 24-24 (2014-02-18)
Acetylcholinesterase (AChE) inhibitors or anticholinesterases reduce the activity of enzyme acetylcholinesterase that degrades the neurotransmitter acetylcholine in the brain. The inhibitors have a significant pharmacological role in neurodegenerative diseases like Alzheimer's and Parkinson's etc. Although plants have been a significant
Muhammad Ayaz et al.
BMC complementary and alternative medicine, 14, 145-145 (2014-06-03)
We investigated Polygonum hydropiper L. (P. hydropiper) for phenolic contents, antioxidant, anticholinesterase activities, in an attempt to rationalize its use in neurological disorders. Plant crude extract (Ph.Cr), its subsequent fractions: n-hexane (Ph.Hex), chloroform (Ph.Chf), ethyl acetate (Ph.EtAc), n-Butanol (Ph.Bt), aqueous
Bin Hao et al.
Molecules (Basel, Switzerland), 18(3), 2458-2468 (2013-02-27)
Phytochemical investigation of the 80% ethanol extract of the bulbs of Lycoris radiata resulted in the isolation of five new Amaryllidaceae alkaloids: (+)-5,6-dehydrolycorine (1), (+)-3α,6β-diacetyl-bulbispermine (2), (+)-3α-hydroxy-6β-acetyl- bulbispermine (3), (+)-8,9-methylenedioxylhomolycorine-N-oxide (5), and 5,6-dihydro-5- methyl-2-hydroxyphenanthridine (7), together with two known compounds
Kenia L Vanzolini et al.
Journal of medicinal chemistry, 56(5), 2038-2044 (2013-01-22)
The use of immobilized capillary enzyme reactors (ICERs) for online ligand screening has been adopted as a new technique for high-throughput screening (HTS). In this work, the selected target was the enzyme acetylcholinesterase (AChE), and the AChE-ICERs produced were used
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