1143008

Cocaine hydrochloride

United States Pharmacopeia (USP) Reference Standard

• Sinonimo/i: Ecgonine methyl ester benzoate hydrochloride
• Formula empirica (notazione di Hill): C₁₇H₂₁NO₄ · HCl
• Numero CAS: 53-21-4
• Peso molecolare: 339.81
• NACRES: NA.24
• PubChem Substance ID: 329749446
• UNSPSC Code: 41116107
• MDL number: MFCD00058119

Proprietà

• grade: pharmaceutical primary standard
• API family: cocaine
• manufacturer/tradename: USP
• drug control: kontrollierte Droge in Deutschland, USDEA Schedule II; regulated under CDSA - not available from Sigma-Aldrich Canada; estupefaciente (Spain); Decreto Lei 15/93: Tabela IB (Portugal)
• application(s): pharmaceutical (small molecule)
• format: neat
• SMILES string: Cl.COC(=O)[C@H]1[C@H](C[C@@H]2CC[C@H]1N2C)OC(=O)c3ccccc3
• InChI: 1S/C17H21NO4.ClH/c1-18-12-8-9-13(18)15(17(20)21-2)14(10-12)22-16(19)11-6-4-3-5-7-11;/h3-7,12-15H,8-10H2,1-2H3;1H/t12-,13+,14-,15+;/m0./s1
• InChI key: PIQVDUKEQYOJNR-VZXSFKIWSA-N

Descrizione

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including MSDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Cocaine hydrochloride USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:

• Cocaine
• Cocaine Hydrochloride
• Cocaine Hydrochloride Tablets for Topical Solution

Biochem/physiol Actions

Inhibits the dopamine, norepinephrine, and serotonin transporters with K_is of about 300 nM, 900 nM, and 400 nM, respectively. Unlike amphetamines, it has no effect on catecholamine release.

Inhibits the dopamine, norepinephrine, and serotonin transporters.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

Legal Information

German
Dieses Produkt fällt unter das Betäubungsmittelgesetz (BtMG). Für eine Bestellung dieses Produktes ist eine Erlaubnis nach § 3 BtMG zwingend erforderlich, es sei denn, es greift eine Ausnahme von der Erlaubnispflicht nach § 4 oder § 26 BtMG.

English
This product is subject to the German Narcotics Act. A permit under Section 3 of the German Narcotics Act is mandatory for ordering this product unless an exemption from the permit requirement under Section 4 or Section 26 of the German Narcotics Act applies.

Informazioni sulla sicurezza

• pictograms: GHS06,GHS08
• signalword: Danger
• hcodes: H300 + H330,H336,H361d
• pcodes: P202 - P260 - P264 - P271 - P280 - P304 + P340 + P310
• Hazard Classifications: Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Repr. 2 - STOT SE 3
• target_organs: Central nervous system
• Classe di stoccaggio: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable