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Z101

Zimelidine dihydrochloride

Name: Zimelidine dihydrochloride
Brand: SIGMA

solid

Sinonimo/i:

(Z)-3-(4-Bromophenyl)-N,N-dimethyl-3-(3-pyridinyl)-2-propen-1-amine dihydrochloride

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Informazioni su questo articolo

Formula empirica (notazione di Hill):

C₁₆H₁₇BrN₂ · 2HCl

Numero CAS:

61129-30-4

Peso molecolare:

390.15

NACRES:

NA.77

PubChem Substance ID:

24278138

UNSPSC Code:

12352200

MDL number:

MFCD00069358

Form:

solid

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Proprietà

form

solid

color

white

solubility

0.1 M HCl: 45 mg/mL, H₂O: 66 mg/mL

originator

AstraZeneca

SMILES string

Cl[H].Cl[H].[H]\C(CN(C)C)=C(/c1ccc(Br)cc1)c2cccnc2

InChI

1S/C16H17BrN2.2ClH/c1-19(2)11-9-16(14-4-3-10-18-12-14)13-5-7-15(17)8-6-13;;/h3-10,12H,11H2,1-2H3;2*1H/b16-9-;;

InChI key

CXGURXWCQYHDIR-ULPVBNQHSA-N

Gene Information

human ... HTR1A(3350), HTR1B(3351), HTR1D(3352), HTR1E(3354), HTR1F(3355), HTR2A(3356), HTR2B(3357), HTR2C(3358), HTR3A(3359), HTR3B(9177), HTR3C(170572), HTR3D(200909), HTR3E(285242), HTR4(3360), HTR5A(3361), HTR5B(645694), HTR6(3362), HTR7(3363)

Descrizione

Application

Zimelidine dihydrochloride has been used as a serotonin transport inhibitor to study its inhibitory role in the uptake of exogenous serotonin by bipolar cells.[1]

Biochem/physiol Actions

Zimelidine, an antidepressant, is a specific 5-hydroxytryptamine (5-HT) reuptake inhibitor,[2] that can be used in treating phobic anxiety. It is very effective and can be tolerated well in elderly individuals. This serotonin transport inhibitor[1] is less likely than other antidepressants to have cardiovascular side effects. Unlike other tricyclic antidepressants, Zimelidine might promote weight loss but not weight gain.[3]

Features and Benefits

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by AstraZeneca. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Legal Information

Sold with the permission of Astra AB.

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Questo articolo	SML2635	SML0694	U101
Sigma-Aldrich Z101 Zimelidine dihydrochloride	Sigma-Aldrich SML2635 Z944 hydrochloride	Sigma-Aldrich SML0694 BX-795 hydrochloride	Sigma-Aldrich U101 5-Methylurapidil
form solid	form powder	form powder	form solid
solubility 0.1 M HCl: 45 mg/mL, H₂O: 66 mg/mL	solubility H₂O: 2 mg/mL, clear	solubility DMSO: 15 mg/mL, clear	solubility H₂O: 0.4 mg/mL, 0.1 M HCl: 3.8 mg/mL
color white	color white to beige	color white to light brown	color white
Gene Information human ... HTR1A(3350), HTR1B(3351), HTR1D(3352), HTR1E(3354), HTR1F(3355), HTR2A(3356), HTR2B(3357), HTR2C(3358), HTR3A(3359), HTR3B(9177), HTR3C(170572), HTR3D(200909), HTR3E(285242), HTR4(3360), HTR5A(3361), HTR5B(645694), HTR6(3362), HTR7(3363)	Gene Information -	Gene Information -	Gene Information human ... ADRA1A(148), ADRA1B(147), ADRA1D(146)
originator AstraZeneca	originator -	originator -	originator -