Passa al contenuto
Merck
Tutte le immagini(1)

Documenti fondamentali

Visualizza tutta la documentazione

W4262

Sigma-Aldrich

1400W dihydrochloride

>98%, solid

Sinonimo/i:

N-([3-(aminomethyl)phenyl]methyl)ethanimidamide

Autenticatiper visualizzare i prezzi riservati alla tua organizzazione & contrattuali

Scegli un formato

10 MG
CHF 159.00

CHF 159.00

Check Cart for Availability
Richiedi un ordine bulk
Tutte le immagini(1)

Scegli un formato

Cambia visualizzazione
10 MG
CHF 159.00

About This Item

Formula empirica (notazione di Hill):
C10H15N3 · 2 HCl
Numero CAS:
214358-33-5
Peso molecolare:
250.17
Numero MDL:
MFCD03428622
Codice UNSPSC:
12352200
ID PubChem:
24278778
NACRES:
NA.77

CHF 159.00

Check Cart for Availability
Richiedi un ordine bulk

Saggio

>98%

Stato

solid

Condizioni di stoccaggio

desiccated

Ideatore

GlaxoSmithKline

Condizioni di spedizione

wet ice

Temperatura di conservazione

−20°C

Stringa SMILE

Cl[H].Cl[H].CC(=N)NCc1cccc(CN)c1

InChI

1S/C10H15N3.2ClH/c1-8(12)13-7-10-4-2-3-9(5-10)6-11;;/h2-5H,6-7,11H2,1H3,(H2,12,13);2*1H
WDJHSQZCZGPGAA-UHFFFAOYSA-N

Informazioni sul gene

human ... NOS1(4842) , NOS2(4843) , NOS3(4846)

Applicazioni

1400W dihydrochloride has been used:
  • as a strong inhibitor of inducible nitric oxide to analyse its effect on intestinal ischemia/reperfusion (I/R) injury model in rat[1]
  • as inducible nitric oxide synthase (iNOS)-selective inhibitor, to elucidate the mechanism of PM10-induced endothelial dysfunction[2]
  • to study its efficacy on renal ischemia/ reperfusion injury in rats[3]
  • as iNOS inhibitor to investigate its ability to counteract spatial memory deficits after hypobaric hypoxia reoxygenation[4]

Azioni biochim/fisiol

1400W dihydrochloride is a potent and selective inhibitor of inducible nitric oxide synthase (iNOS).

Caratteristiche e vantaggi

This compound is featured on the Nitric Oxide Synthases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

Scegli una delle versioni più recenti:

Certificati d'analisi (COA)

Lot/Batch Number
0000132679
0000132679
075M4610V
055M4609V
091M4621V

Non trovi la versione di tuo interesse?

Se hai bisogno di una versione specifica, puoi cercare il certificato tramite il numero di lotto.

Cerca un COA

Possiedi già questo prodotto?

I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.

Visita l’Archivio dei documenti

I clienti hanno visto anche

Slide 1 of 6

1 of 6

Nω-Nitro-L-arginine ≥98% (TLC)

Sigma-Aldrich

N5501

Nω-Nitro-L-arginine

L-Canavanine ≥98% (TLC), powder, from Canavalia ensiformis

Sigma-Aldrich

C1625

L-Canavanine

NG-Nitro-L-arginine Methyl Ester, Hydrochloride Cell permeable. More soluble analog of arginine and a competitive, slowly reversible inhibitor of eNOS (IC₅₀ = 500 nM). Causes a prolonged inhibition of acetylcholine-induced relaxation of rat aortic rings (IC₅₀ = 400 nM).

Sigma-Aldrich

483125-M

NG-Nitro-L-arginine Methyl Ester, Hydrochloride

Diphenyleneiodonium chloride ≥98%

Sigma-Aldrich

D2926

Diphenyleneiodonium chloride

Mifepristone ≥98%

Sigma-Aldrich

M8046

Mifepristone

Coenzyme Q10 ≥98% (HPLC)

Sigma-Aldrich

C9538

Coenzyme Q10

Jieyu Xu et al.
International journal of biological sciences, 16(9), 1563-1574 (2020-04-01)
The production of nitric oxide (NO) is a key feature of immunosuppressive myeloid cells, which impair T cell activation and proliferation via reversibly blocking interleukin-2 receptor signaling. NO is mainly produced from L-arginine by inducible NO synthase (iNOS). Moreover, L-arginine
Simone Bido et al.
Nature communications, 12(1), 6237-6237 (2021-10-31)
Recent findings in human samples and animal models support the involvement of inflammation in the development of Parkinson's disease. Nevertheless, it is currently unknown whether microglial activation constitutes a primary event in neurodegeneration. We generated a new mouse model by
L L Thomsen et al.
Cancer research, 57(15), 3300-3304 (1997-08-01)
We have investigated the effect of N-(3-(aminomethyl)benzyl)acetamidine (1400W), a novel and highly selective inhibitor for inducible NOS (iNOS), on in vivo growth of solid tumors expressing iNOS. For the EMT6 murine mammary adenocarcinoma, in which iNOS is expressed in the
Melatonin and 1400 W ameliorate both intestinal and remote organ injury following mesenteric ischemia/reperfusion
Kesik V, et al.
The Journal of Surgical Research, 157(1), e97-e105 (2009)
Comparison of the efficacy of melatonin and 1400W on renal ischemia/reperfusion injury: a role for inhibiting iNOS
Ersoz N, et al.
Renal Failure, 31(8), 704-710 (2009)
Visualizza tutti i documenti correlati

Articoli

DISCOVER Bioactive Small Molecules for Nitric Oxide & Cell Stress Research

DISCOVER Bioactive Small Molecules for Nitric Oxide & Cell Stress Research

Questions

Reviews

No rating value

Active Filters

Il team dei nostri ricercatori vanta grande esperienza in tutte le aree della ricerca quali Life Science, scienza dei materiali, sintesi chimica, cromatografia, discipline analitiche, ecc..

Contatta l'Assistenza Tecnica.