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UC167

Oxidized Nifedipine

Name: Oxidized Nifedipine
Brand: SIGMA

powder, ~95% (HPLC)

Sinonimo/i:

2,6-Dimethyl-4-(2´-nitrophenyl)-3,5-pyridinecarboxylic acid dimethyl ester

Autenticati per visualizzare i prezzi organizzativi e contrattuali.

Informazioni su questo articolo

Formula empirica (notazione di Hill):

C₁₇H₁₆N₂O₆

Numero CAS:

67035-22-7

Peso molecolare:

344.32

NACRES:

NA.77

PubChem Substance ID:

329827652

UNSPSC Code:

12161501

MDL number:

MFCD00153847

Assay:

~95% (HPLC)

Form:

powder

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Proprietà

assay

~95% (HPLC)

Quality Segment

200

form

powder

color

yellow

mp

100-105 °C

storage temp.

2-8°C

SMILES string

COC(=O)c1c(C)nc(C)c(C(=O)OC)c1-c2ccccc2[N+]([O-])=O

InChI

1S/C17H16N2O6/c1-9-13(16(20)24-3)15(14(10(2)18-9)17(21)25-4)11-7-5-6-8-12(11)19(22)23/h5-8H,1-4H3

InChI key

UMQHJQGNGLQJPF-UHFFFAOYSA-N

Descrizione

Application

Oxidized nifedipine has been used for apoptotic signaling studies in dopaminergic neurons[1].

Oxidized Nifedipine may be used:

to study enzyme kinetics using UV high-performance liquid chromatography (UV-HPLC)
as a standard in calibration curve preparation in high-performance liquid chromatography (HPLC) for the quantification of cytochrome P450 3A4 (CYP3A4)-mediated nifedipine oxidation in human microsomes[2]
in nifedipine metabolism activity assay of Hep G2 cells transfected with hepatocyte nuclear factor-1α(HNF1α)[3]

Biochem/physiol Actions

CYP3A4 nifedipine metabolite. Nifedipine (parent compound) is an antianginal and antihypertensive agent.

Nifedipine is a dihydropyridine derivative[4] and a calcium channel blocker.[5] It is used in treating hypertension and angina pectoris.[4] Oxidized Nifedipine is an oxidation product of nifedipine generated either by exposure to UV or day light.[5] The enzyme cytochrome P450 3A (CYP3A4) metabolizes nifedipine.[3]

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

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Questo articolo	N7634	N7510	N0165
Sigma-Aldrich UC167 Oxidized Nifedipine	Sigma-Aldrich N7634 Nifedipine	Sigma-Aldrich N7510 Nicardipine hydrochloride	Sigma-Aldrich N0165 Nisoldipine
form powder	form powder	form powder	form powder
assay ~95% (HPLC)	assay ≥98% (HPLC)	assay ≥98%	assay ≥98% (HPLC)
Quality Level 200	Quality Level 200	Quality Level 100	Quality Level 100
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. room temp
color yellow	color yellow	color yellow	color yellow
mp 100-105 °C	mp -	mp -	mp -