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T6258

Triosephosphate Isomerase from rabbit muscle

Type X, lyophilized powder, ≥3,500 units/mg protein

Sinonimo/i:

D-Glyceraldehyde-3-phosphate ketol-isomerase, TPI

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Taglio della confezioneSKUDisponibilitàPrezzo
1 mg
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CHF 95.30
5 mg
Per conoscere la disponibilità, visualizza il carrello
CHF 380.00

Informazioni su questo articolo

Numero CAS:
9023-78-3
UNSPSC Code:
12352204
NACRES:
NA.54
EC Number:
232-774-2
MDL number:
MFCD00082080
Numero CE:
5.3.1.1 (BRENDA, IUBMB)
Specific activity:
≥3,500 units/mg protein

CHF 95.30

Per conoscere la disponibilità, visualizza il carrello
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type

Type X

Quality Level

200

form

lyophilized powder

specific activity

≥3,500 units/mg protein

mol wt

calculated mol wt 53.2 kDa

composition

Protein, 60-90% biuret

foreign activity

pyruvate kinase, lactic dehydrogenase, 3-phosphoglyceric phosphokinase, phosphoglucose isomerase, α-glycerophosphate dehydrogenase, aldolase and glyceraldehyde-3-phosphate dehydrogenase ≤0.01%

storage temp.

−20°C

General description

Triosephosphate isomerase (TPI) gene is located on human chromosome 12p13. It is expressed in all tissues. This homodimer of two 27 kDa subunits is highly stable and is made up of 248 amino acids. TPI is catalytically active in its dimeric state.

Application

Triosephosphate Isomerase from rabbit muscle has been complexed with p-hydroxymercurybenzoate (PHMB) to denature the protein for hydrophobic interaction chromatography coupled online with chemical vapour atomic fluorescence spectrometry (HIC−CVGAFS).
Triosephosphate isomerase has been used in a study to assess changes in cardiac energy metabolic pathways in overweight rats fed a high-fat diet. Triosephosphate isomerase has also been used in a study to investigate proteomic identification of carbonylated proteins in F344 rat hippocampus after 1-bromopropane exposure. [1]

Biochem/physiol Actions

Triosephosphate isomerase (TPI) is responsible for the catalysis of the triose phosphate isomers, dihydroxyacetone phosphate and glyceraldehyde 3-phosphate. TPI deficiency is associated with glycolytic enzymopathy. Lack of TPI is also associated with chronic hemolytic anemia, enhanced exposure to bacterial infections, cardiomyopathy and neuromuscular disease.

Packaging

Package size based on protein content

Physical form

Sulfate-free, contains EDTA and borate buffer salts

Other Notes

One unit will convert 1.0 μmole D-glyceraldehyde 3-phosphate to dihydroxyacetone phosphate per min at pH 7.6 at 25 °C.

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Questo articolo
T2391P9544P6635
Triosephosphate Isomerase from rabbit muscle Type X, lyophilized powder, ≥3,500 units/mg protein

Sigma-Aldrich

T6258

Triosephosphate Isomerase from rabbit muscle

Triosephosphate Isomerase from rabbit muscle Type III-S, ammonium sulfate suspension, ≥4,000 units/mg protein

Sigma-Aldrich

T2391

Triosephosphate Isomerase from rabbit muscle

Phosphoglucose Isomerase from rabbit muscle Type XI, lyophilized powder, ≥200 units/mg protein

Sigma-Aldrich

P9544

Phosphoglucose Isomerase from rabbit muscle

Phosphorylase b from rabbit muscle lyophilized powder, ≥20 units/mg protein, 2× crystallization

Sigma-Aldrich

P6635

Phosphorylase b from rabbit muscle

specific activity

≥3,500 units/mg protein

specific activity

≥4,000 units/mg protein

specific activity

≥200 units/mg protein

specific activity

≥20 units/mg protein

form

lyophilized powder

form

ammonium sulfate suspension

form

lyophilized powder

form

lyophilized powder

mol wt

calculated mol wt 53.2 kDa

mol wt

calculated mol wt 53.2 kDa

mol wt

-

mol wt

97,200 Da by calculation

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

−20°C

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

300

foreign activity

pyruvate kinase, lactic dehydrogenase, 3-phosphoglyceric phosphokinase, phosphoglucose isomerase, α-glycerophosphate dehydrogenase, aldolase and glyceraldehyde-3-phosphate dehydrogenase ≤0.01%

foreign activity

3-phosphoglyceric phosphokinase ≤0.01%, glyceraldehyde-3-phosphate dehydrogenase ≤0.01%, pyruvate kinase, lactic dehydrogenase, phosphoglucose isomerase, α-glycerophosphate dehydrogenase and aldolase ≤0.001%

foreign activity

-

foreign activity

phosphoglucomutase ≤1.0%, phosphorylase a ≤10%, phosphorylase kinase ≤0.5%, phosphorylase phosphatase, debrancher enzyme, AMPase and ATPase ≤0.1%

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11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificati d'analisi (COA)

Lot/Batch Number
0000541926
0000541926
0000518467
0000518467
0000505602

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Contenuto correlato

Red blood cell enzymopathies
Hematology, 616-625 (2018)
Triosephosphate isomerase deficiency: new insights into an enigmatic disease
Orosz F, et al.
Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 1792(12), 1168-1174 (2009)
Hydrophobic interaction chromatography coupled with atomic fluorescence spectrometric detection: Effect of the denaturation on the determination of thiolic proteins
Bramanti E, et al.
Talanta, 63(2), 383-389 (2004)
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Numero articolo commerciale globale

SKUGTIN
T6258-1MG04061837358517
T6258-5MG04061833274682

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