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T182

Tyrphostin A9

solid

Sinonimo/i:

Malonoben, [[3,5-bis(1,1-Dimethylethyl)-4-hydroxyphenyl]methylene]propanedinitrile

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Cambia visualizzazione
Taglio della confezioneSKUDisponibilitàPrezzo
5 mg
Per conoscere la disponibilità, visualizza il carrello
CHF 109.00
CHF 92.65
25 mg
Per conoscere la disponibilità, visualizza il carrello
CHF 284.00

Informazioni su questo articolo

Formula empirica (notazione di Hill):
C18H22N2O
Numero CAS:
10537-47-0
Peso molecolare:
282.38
NACRES:
NA.77
PubChem Substance ID:
24278069
UNSPSC Code:
51111800
MDL number:
MFCD00209853
Assay:
≥98% (HPLC)
Form:
solid
Quality level:
100

CHF 92.65

Prezzo di listinoCHF 109.00Risparmia il 15%
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biological source

synthetic (organic)

Quality Level

100

assay

≥98% (HPLC)

form

solid

color

yellow

mp

139-140 °C

solubility

ethanol: 20 mg/mL, DMSO: <25 mg/mL, H2O: insoluble

SMILES string

CC(C)(C)c1cc(\C=C(\C#N)C#N)cc(c1O)C(C)(C)C

InChI

1S/C18H22N2O/c1-17(2,3)14-8-12(7-13(10-19)11-20)9-15(16(14)21)18(4,5)6/h7-9,21H,1-6H3

InChI key

MZOPWQKISXCCTP-UHFFFAOYSA-N

Gene Information

human ... EGFR(1956), ORAI1(84876), PDGFRA(5156), PDGFRB(5159)
mouse ... Eef2k(13631), Prkaca(18747), Prkca(18750), Src(20779)

Application

Tyrphostin A9 can be used for inhibiting tyrosine kinase functions in C2C12 cells[1]. It has also been used to disrupt membrane potential in mammalian cells[2].

Biochem/physiol Actions

Tyrphostin A9 is a PDGF receptor tyrosine kinase inhibitor that can induce apoptosis in cancer cells[3], inhibit the growth of vascular smooth cells[4] and block calcium release-dependent phosphorylations[5].

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Preparation Note

Tyrphostin A9 is soluble in ethanol at 20 mg/ml, in DMSO at a concentration less than 25 mg/ml. It is insoluble in water.

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Questo articolo
SML1206T1443S4194
Tyrphostin A9 solid

Sigma-Aldrich

T182

Tyrphostin A9

RA-9 &#8805;98% (HPLC)

Sigma-Aldrich

SML1206

RA-9

TCPOBOP &#8805;98% (HPLC), solid

Sigma-Aldrich

T1443

TCPOBOP

SR 12813 &#8805;98%, solid

Sigma-Aldrich

S4194

SR 12813

form

solid

form

powder

form

solid

form

solid

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98%

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

solubility

ethanol: 20 mg/mL, H2O: insoluble, DMSO: <25 mg/mL

solubility

DMSO: 2 mg/mL, clear (warmed)

solubility

DMSO: >10 mg/mL, H2O: insoluble

solubility

DMSO: ≥10 mg/mL, H2O: insoluble

color

yellow

color

white to beige

color

white

color

-

Gene Information

human ... EGFR(1956), ORAI1(84876), PDGFRA(5156), PDGFRB(5159)
mouse ... Eef2k(13631), Prkaca(18747), Prkca(18750), Src(20779)

Gene Information

-

Gene Information

human ... NR1I3(9970)

Gene Information

-

pictograms

Skull and crossbones
GHS06

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Oral

Classe di stoccaggio

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

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Certificati d'analisi (COA)

Lot/Batch Number
MKCV7328
MKCT9315
MKCS3755
MKCR8771
MKCH0037

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So Jung Park et al.
Biochemical and biophysical research communications, 408(3), 465-470 (2011-04-30)
Mitochondria dynamics controls not only their morphology but also functions of mitochondria. Therefore, an imbalance of the dynamics eventually leads to mitochondria disruption and cell death. To identify specific regulators of mitochondria dynamics, we screened a bioactive chemical compound library
J Thyberg
European journal of cell biology, 76(1), 33-42 (1998-07-03)
To proliferate, vascular smooth muscle cells first convert from a contractile to a synthetic phenotype. Earlier studies indicate that this process is supported by fibronectin and accelerated by platelet-derived growth factor (PDGF). Here, the mechanisms in this transition were further
Naveen Kumar et al.
Journal of virology, 85(6), 2818-2827 (2011-01-07)
Host signaling pathways play important roles in the replication of influenza virus, but their functional effects remain to be characterized at the molecular level. Here we identify two receptor tyrosine kinase inhibitors (RTKIs) of the tyrphostin class that exhibit robust
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Numero articolo commerciale globale

SKUGTIN
SAB1305340-400UL04061835614097
T182-5MG04061832434865
T182-25MG04061832434858

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