T1014

TNPAL-Sphingomyelin

1 mg/mL in chloroform/methanol (2:1)

• Sinonimo/i: Trinitrophenylaminolauroylsphingomyelin
• Formula empirica (notazione di Hill): C₄₁H₇₃N₆O₁₂P
• Numero CAS: 117985-56-5
• Peso molecolare: 873.03
• UNSPSC Code: 12352211
• PubChem Substance ID: 24899923
• MDL number: MFCD00133879

Proprietà

• assay: ≥98% (TLC)
• form: liquid
• concentration: 1 mg/mL in chloroform/methanol (2:1)
• storage temp.: −20°C
• SMILES string: CCCCCCCCCCCCC\C=C\[C@H](O)[C@@H](COP(O)(=O)OCC[N](C)(C)C)NC(=O)CCCCCCCCCCCNc1c(cc(cc1N(=O)=O)N(=O)=O)N(=O)=O
• InChI: 1S/C41H74N6O12P/c1-5-6-7-8-9-10-11-12-13-15-18-21-24-27-39(48)36(34-59-60(56,57)58-31-30-47(2,3)4)43-40(49)28-25-22-19-16-14-17-20-23-26-29-42-41-37(45(52)53)32-35(44(50)51)33-38(41)46(54)55/h24,27,32-33,36,39,42,48H,5-23,25-26,28-31,34H2,1-4H3,(H,43,49)(H,56,57)/b27-24+
• InChI key: ZAKSUDRQGDIXGH-SOYKGTTHSA-N

Descrizione

General description

Substrate for microbial and animal sphingomyelinases.

Application

TNPAL-Sphingomyelin was used as substrate to determine the activity of sphingomyelinase spectrophotometrically.[1][2][3]

Biochem/physiol Actions

Sphingomyelin (SM) is a sphingolipid found in the myelin sheath and cell membranes of animals. The regulation of SM content by sphingomyelinase and SM synthase 2 affect the membrane properties and signaling.[4] Excess oxysterols result in increased amount of SM and calcium ions that is the main reason for artery blockage and atherosclerosis.[5]

Informazioni sulla sicurezza

• pictograms: GHS02,GHS06,GHS08
• signalword: Danger
• hcodes: H225,H302 + H312,H315,H319,H331,H336,H351,H361d,H370,H372
• pcodes: P201 - P210 - P280 - P302 + P352 + P312 - P304 + P340 + P311 - P308 + P311
• Hazard Classifications: Acute Tox. 3 Inhalation - Acute Tox. 4 Dermal - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Flam. Liq. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 1 - STOT SE 3
• target_organs: Central nervous system, Eyes
• Classe di stoccaggio: 3 - Flammable liquids
• wgk: WGK 3
• flash_point_f: 51.8 °F - closed cup
• flash_point_c: 11 °C - closed cup
• ppe: Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter