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T0938

Anti-Tumor Necrosis Factor-α antibody produced in goat

Name: Anti-Tumor Necrosis Factor-α antibody produced in goat
Brand: SIGMA

affinity isolated antibody, lyophilized powder

Sinonimo/i:

Anti-TNF-α

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Informazioni su questo articolo

NACRES:

NA.41

UNSPSC Code:

51111800

Conjugate:

unconjugated

Clone:

polyclonal

Application:

ELISA (c), FACS, IF, Neutral, WB

Citations:

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Servizio Tecnico

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Proprietà

biological source

goat

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

lyophilized powder

species reactivity

mouse

technique(s)

capture ELISA: suitable, flow cytometry: 5-25 μg/mL, indirect immunofluorescence: 15 μg/mL using mouse cells and tissues, neutralization: suitable, western blot: 0.1-0.2 μg/mL

UniProt accession no.

P06804

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

mouse ... Tnf(21926)

Descrizione

General description

Tumor Necrosis Factor-α (TNF-α) is a protein produced by lipopolysaccharide-stimulated macrophages and causes tumor necrosis. It also facilitates many functions like stimulate growth of human fibroblasts and other cell lines, activate polymorphonuclear neutrophils and osteoclasts and collagenase production. Anti-Tumor Necrosis Factor-α antibody can be used for neutralizing the biological activity of recombinant mouse TNF-α. It can also be used in indirect immunofluorescence. Goat anti-Tumor Necrosis Factor-α antibody reacts specifically with recombinant mouse TNF-α.

Immunogen

recombinant mouse TNF-α

Application

Anti-Tumor Necrosis Factor-α antibody can be used in ELISA capture and flow cytometry. It can also be used in immunoblotting.

Biochem/physiol Actions

The antibody neutralizes the biological activity of recombinant mouse TNF-α.

Physical form

Lyophilized from 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.

Preparation Note

Purified using mouse TNF-α affinity chromatography.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Questo articolo	T1815	T2824	T3198
Sigma-Aldrich T0938 Anti-Tumor Necrosis Factor-α antibody produced in goat	Sigma-Aldrich T1815 Monoclonal Anti-Tumor Necrosis Factor Receptor II antibody produced in mouse	Sigma-Aldrich T2824 Monoclonal Anti-Tumor Necrosis Factor-α antibody produced in hamster	Sigma-Aldrich T3198 Monoclonal Anti-Tumor Necrosis Factor-α antibody produced in mouse
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
antibody form affinity isolated antibody	antibody form purified immunoglobulin	antibody form purified immunoglobulin	antibody form purified immunoglobulin
Quality Level 100	Quality Level 200	Quality Level 200	Quality Level 100
biological source goat	biological source mouse	biological source hamster	biological source mouse
form lyophilized powder	form lyophilized powder	form buffered aqueous solution	form lyophilized powder
technique(s) capture ELISA: suitable, indirect immunofluorescence: 15 μg/mL using mouse cells and tissues, western blot: 0.1-0.2 μg/mL, flow cytometry: 5-25 μg/mL, neutralization: suitable	technique(s) immunocytochemistry: 8-25 μg/mL using immersion fixed human peripheral blood lymphocytes, microarray: suitable, neutralization: suitable	technique(s) immunoprecipitation (IP): suitable, indirect ELISA: suitable, microarray: suitable, neutralization: suitable, western blot: 0.25-0.5 μg/mL using recombinant mouse TNF-α	technique(s) capture ELISA: suitable, neutralization: suitable, western blot: 1-2 μg/mL

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Classe di stoccaggio

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Contenuto correlato

Data Sheet - T0938

An endotoxin-induced serum factor that causes necrosis of tumors.

E A Carswell et al.

Proceedings of the National Academy of Sciences of the United States of America, 72(9), 3666-3670 (1975-09-01)

In studying "hemorrhagic necrosis" of tumors produced by endotoxin, it was found that the serum of bacillus Calmette--Guerin (BCG)-infected mice treated with endotoxin contains a substance (tumor necrosis factor; TNF) which mimics the tumor necrotic action of endotoxin itself. TNF-positive

Stimulation of bone resorption and inhibition of bone formation in vitro by human tumour necrosis factors.

D R Bertolini et al.

Nature, 319(6053), 516-518 (1986-02-06)

When leukocytes are exposed to mitogens or antigens in vitro, they release bone-resorbing activity into the culture supernatants which can be detected by bioassay. Like many lymphocyte-monocyte products, this activity has been difficult to purify because of its low abundance

Cachectin/tumor necrosis factor stimulates collagenase and prostaglandin E2 production by human synovial cells and dermal fibroblasts.

J M Dayer et al.

The Journal of experimental medicine, 162(6), 2163-2168 (1985-12-01)

Cachectin/TNF (tumor necrosis factor), an endotoxin-induced murine macrophage hormone implicated in the pathogenesis of cachexia and shock, has been found capable of stimulating collagenase and prostaglandin E2 (PGE2) production by isolated human synovial cells and dermal fibroblasts. This bioactivity associated

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Numero articolo commerciale globale

SKU	GTIN
T0938-.1MG	04061832717234

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