S0127

Sulfathiazole sodium salt

≥99%

• Sinonimo/i: 4-Amino-N-(2-thiazolyl)benzenesulfonamide sodium salt
• Formula empirica (notazione di Hill): C₉H₈N₃NaO₂S₂
• Numero CAS: 144-74-1
• Peso molecolare: 277.30
• UNSPSC Code: 51283955
• NACRES: NA.85
• PubChem Substance ID: 24899426
• EC Number: 205-638-5
• Beilstein/REAXYS Number: 3802297
• MDL number: MFCD00072133

Proprietà

• biological source: synthetic (Organic)
• assay: ≥99%
• form: powder
• color: white to off-white
• solubility: H₂O: soluble 50 mg/mL
• antibiotic activity spectrum: Gram-negative bacteria, Gram-positive bacteria, mycoplasma
• mode of action: DNA synthesis | interferes, enzyme | inhibits
• SMILES string: Nc1ccc(cc1)S(=O)(=O)N([Na])c2nccs2
• InChI: 1S/C9H8N3O2S2.Na/c10-7-1-3-8(4-2-7)16(13,14)12-9-11-5-6-15-9;/h1-6H,10H2;/q-1;+1
• InChI key: GWIJGCIVKLITQK-UHFFFAOYSA-N

Descrizione

General description

Chemical structure: sulfonamide

Application

Sulfathiazole is a short-acting sulfa drug. It was a common oral and topical antibiotic until less toxic alternatives were discovered. It is no longer used in humans[1]. Sulfathiazole is added to the diet of laboratory animals to inhibit folate formation by gut bacteria. This ensures that the animal′s only source of available folate is from their diet[2].

Biochem/physiol Actions

Sulfathiazole is a sulfonamide antibiotic that blocks the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase. Sulfathiazole is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), which is required for bacterial synthesis of folic acid[1]. It is active against Gram positive bacteria, Gram negative bacteria and Chlamydia. Mode of resistance is via the alteration of dihydropteroate synthase or alternative pathway for folic acid synthesis.

Other Notes

Keep container tightly closed in a dry and well-ventilated place.

Informazioni sulla sicurezza

• pictograms: GHS07
• signalword: Warning
• hcodes: H315,H319,H335
• pcodes: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Classe di stoccaggio: 11 - Combustible Solids
• wgk: WGK 2
• ppe: dust mask type N95 (US), Eyeshields, Gloves