Documenti fondamentali

Visualizza tutta la documentazione

Vai a

P0035

Penciclovir

Name: Penciclovir
Brand: SIGMA

Sinonimo/i:

2-Amino-1,9-dihydro-9-[4-hydroxy-3-(hydroxymethyl)butyl]-6H-purin-6-one, BRL-39123

Autenticati per visualizzare i prezzi organizzativi e contrattuali.

Scegli un formato

Cambia visualizzazione

Taglio della confezione	SKU	Disponibilità	Prezzo

Informazioni su questo articolo

Formula empirica (notazione di Hill):

C₁₀H₁₅N₅O₃

Numero CAS:

39809-25-1

Peso molecolare:

253.26

NACRES:

NA.76

PubChem Substance ID:

329819986

UNSPSC Code:

51102829

MDL number:

MFCD15142866

Prezzi e disponibilità al momento non sono disponibili

Servizio Tecnico

Hai bisogno di aiuto? Il nostro team di scienziati qualificati è a tua disposizione.

Permettici di aiutarti

Proprietà

form

powder

Quality Level

100

solubility

0.02 M potassium phosphate: soluble 2 mg/mL

antibiotic activity spectrum

viruses

mode of action

DNA synthesis | interferes, enzyme | inhibits

SMILES string

NC1=NC(=O)c2ncn(CCC(CO)CO)c2N1

InChI

1S/C10H15N5O3/c11-10-13-8-7(9(18)14-10)12-5-15(8)2-1-6(3-16)4-17/h5-6,16-17H,1-4H2,(H3,11,13,14,18)

InChI key

JNTOCHDNEULJHD-UHFFFAOYSA-N

Descrizione

Application

Penciclovir is a selective antiherpesvirus agent, particularly against herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) and varicella-zoster virus (VZV)[1].

Biochem/physiol Actions

Penciclovir is converted to its active form, penciclovir triphosphate, by cellular kinases. It inhibits viral DNA polymerase by competing with deoxyguanosine triphosphate. It inhibits DNA synthesis of virus-infected cells. Penciclovir has in vitro activity against herpes simplex virus types 1 (HSV-1) and 2 (HSV-2). It does not inhibit DNA synthesis in non-infected cells. Mode of resistance is via qualitative changes in viral thymidine kinase or DNA polymerase[2].

Other Notes

Keep container tightly closed in a dry and well-ventilated place.

Confronta articoli simili

Visualizza il confronto per intero

Mostra le differenze

1 of 1

Questo articolo	SML1103	G2536	PHR1593
Sigma-Aldrich P0035 Penciclovir	Sigma-Aldrich SML1103 Entecavir	Sigma-Aldrich G2536 Ganciclovir	Supelco PHR1593 Ganciclovir
antibiotic activity spectrum viruses	antibiotic activity spectrum -	antibiotic activity spectrum viruses	antibiotic activity spectrum -
mode of action DNA synthesis \| interferes, enzyme \| inhibits	mode of action -	mode of action DNA synthesis \| interferes	mode of action -
form powder	form powder	form powder	form -
solubility 0.02 M potassium phosphate: soluble 2 mg/mL	solubility H₂O: 0.5 mg/mL, clear (warmed)	solubility 0.1 M HCl: 10 mg/mL	solubility -
Quality Level 100	Quality Level 100	Quality Level 300	Quality Level 300

Still not finding the right product?

Explore all of our products under

Classe di stoccaggio

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Scegli una delle versioni più recenti:

Certificati d'analisi (COA)

Lot/Batch Number

Non trovi la versione di tuo interesse?

Se hai bisogno di una versione specifica, puoi cercare il certificato tramite il numero di lotto.

Cerca un COA

Possiedi già questo prodotto?

I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.

Visita l’Archivio dei documenti

PET imaging of thymidine kinase gene expression in the liver of non-human primates following systemic delivery of an adenoviral vector.

A Fontanellas et al.

Gene therapy, 16(1), 136-141 (2008-08-01)

Non-invasive in vivo imaging of transgene expression is currently providing very important means to optimize gene therapy regimes. Results in non-human primates are considered the most predictive models for the outcome in patients. In this study, we have documented that

Penciclovir cream--improved topical treatment for herpes simplex infections.

M-H Schmid-Wendtner et al.

Skin pharmacology and physiology, 17(5), 214-218 (2004-09-29)

Human herpesviruses can be found worldwide and cause many viral infections in immunocompetent as well as in immunocompromised patients. Herpes simplex virus (HSV) diseases can be the cause of life-threatening disease, especially in neonates. After initial infection, HSV persists latently

Resistance of herpes simplex viruses to nucleoside analogues: mechanisms, prevalence, and management.

Jocelyne Piret et al.

Antimicrobial agents and chemotherapy, 55(2), 459-472 (2010-11-17)

Herpes simplex viruses (HSV) type 1 and type 2 are responsible for recurrent orolabial and genital infections. The standard therapy for the management of HSV infections includes acyclovir (ACV) and penciclovir (PCV) with their respective prodrugs valacyclovir and famciclovir. These

Visualizza tutti i documenti correlati

Numero articolo commerciale globale

SKU	GTIN
P0035-100MG	04061832991795

Questions

Reviews

No rating value