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N8010

4-Nitrophenyl 4-guanidinobenzoate hydrochloride

protease substrate, ≥95.0% (TLC), powder

Sinonimo/i:

4-Guanidinobenzoic acid 4-nitrophenylester hydrochloride, NPGB, pNPGB

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Cambia visualizzazione
Taglio della confezioneSKUDisponibilitàPrezzo
500 mg
Per conoscere la disponibilità, visualizza il carrello
CHF 338.00
1 g
Per conoscere la disponibilità, visualizza il carrello
CHF 461.00
CHF 391.85

Informazioni su questo articolo

Formula empirica (notazione di Hill):
C14H12N4O4 · HCl
Numero CAS:
19135-17-2
Peso molecolare:
336.73
NACRES:
NA.32
PubChem Substance ID:
24897847
UNSPSC Code:
12352204
EC Number:
242-831-3
MDL number:
MFCD00037010
Beilstein/REAXYS Number:
8024554

CHF 338.00

Per conoscere la disponibilità, visualizza il carrello
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Nome del prodotto

4-Nitrophenyl 4-guanidinobenzoate hydrochloride, protease inhibitor and substrate

Quality Level

200

assay

≥95.0% (TLC)

form

powder

solubility

formic acid: soluble 49.00-51.00 mg/mL

storage temp.

−20°C

SMILES string

Cl[H].NC(=N)Nc1ccc(cc1)C(=O)Oc2ccc(cc2)[N+]([O-])=O

InChI

1S/C14H12N4O4.ClH/c15-14(16)17-10-3-1-9(2-4-10)13(19)22-12-7-5-11(6-8-12)18(20)21;/h1-8H,(H4,15,16,17);1H

InChI key

PKSBDZOBYIKNGY-UHFFFAOYSA-N

General description

4-Nitrophenyl 4-guanidinobenzoate hydrochloride (pNPGB) is a trypsin substrate. It is more water-soluble than 4-methylumbelliferyl 4-guanidinobenzoate and is preferred in spectrophotometric assay.[1]

Application

4-Nitrophenyl 4-guanidinobenzoate hydrochloride has been used:
  • as a substrate for trypsin for active site titration experiments
  • for pre-treating of mosquito eggs in the interplasmid transposition assay [2]
  • as a component of isotonic buffer to moisten filter paper for mosquito embryo collection[3]

Biochem/physiol Actions

4-Nitrophenyl 4-guanidinobenzoate hydrochloride (pNPGB) inhibits phenoloxidase enzyme and delays embryo chorionic membrane hardening.[3]

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Questo articolo
N162773677N2127
4-Nitrophenyl 4-guanidinobenzoate hydrochloride protease inhibitor and substrate

Sigma-Aldrich

N8010

4-Nitrophenyl 4-guanidinobenzoate hydrochloride

4-Nitrophenyl β-D-glucuronide ≥98% (TLC)

Sigma-Aldrich

N1627

4-Nitrophenyl β-D-glucuronide

4-Nitrophenyl β-D-glucuronide ≥99.0% (TLC)

Sigma-Aldrich

73677

4-Nitrophenyl β-D-glucuronide

4-Nitrophenyl α-D-mannopyranoside α-mannosidase substrate

Sigma-Aldrich

N2127

4-Nitrophenyl α-D-mannopyranoside

assay

≥95.0% (TLC)

assay

≥98% (TLC)

assay

≥99.0% (TLC)

assay

≥98% (TLC)

solubility

formic acid: soluble 49.00-51.00 mg/mL

solubility

H2O: soluble 100 mg/mL, clear

solubility

H2O: 0.1 g/mL, clear, faintly yellow

solubility

DMF: 50 mg/mL

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

300

form

powder

form

powder

form

powder or crystals

form

powder

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

pictograms

Corrosion
GHS05

signalword

Danger

hcodes

H318

Hazard Classifications

Eye Dam. 1

Classe di stoccaggio

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificati d'analisi (COA)

Lot/Batch Number
0000427384
0000427384
0000361401
0000322468
0000322469

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D Collen et al.
The Journal of biological chemistry, 268(11), 8284-8289 (1993-04-15)
The mechanism of activation of human plasminogen by recombinant staphylokinase (STAR) was studied using the active site titrant p-nitrophenyl-p'-guanidinobenzoate (NPGB). NPGB prevented active site exposure in equimolar mixtures of plasminogen and STAR but reacted stoichiometrically with mixtures preincubated in the
S P Leytus et al.
Biochimica et biophysica acta, 788(1), 74-86 (1984-07-17)
A theory and experimental method are presented to characterize the kinetics of fast-acting, irreversible proteinase inhibitors. The theory is based upon formal analysis of the case of an irreversible inhibitor competing with a substrate for the active-site of a proteinase.
Mekdes Debela et al.
Scientific reports, 8(1), 10705-10705 (2018-07-18)
Human KLK8/neuropsin, a kallikrein-related serine peptidase, is mostly expressed in skin and the hippocampus regions of the brain, where it regulates memory formation by synaptic remodeling. Substrate profiles of recombinant KLK8 were analyzed with positional scanning using fluorogenic tetrapeptides and
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Numero articolo commerciale globale

SKUGTIN
N8010-1G04061834118336
N8010-500MG04061834118343

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