N161
NPC-15437 dihydrochloride hydrate
≥97% (NMR), powder
Sinonimo/i:
(S)-2,6-Diamino-N-[(1-(1-oxotridecyl)-2-piperidinyl)methyl]hexanamide dihydrochloride hydrate
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Informazioni su questo articolo
Formula empirica (notazione di Hill):
C25H50N4O2 · 2HCl · xH2O
Numero CAS:
Peso molecolare:
511.61 (anhydrous basis)
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥97% (NMR)
Form:
powder
Storage condition:
desiccated
assay
≥97% (NMR)
form
powder
storage condition
desiccated
color
white
solubility
H2O: 10 mg/mL, clear
storage temp.
2-8°C
SMILES string
Cl[H].Cl[H].CCCCCCCCCCCCC(=O)N1CCCCC1CNC(=O)[C@@H](N)CCCCN
InChI
1S/C25H50N4O2.2ClH/c1-2-3-4-5-6-7-8-9-10-11-18-24(30)29-20-15-13-16-22(29)21-28-25(31)23(27)17-12-14-19-26;;/h22-23H,2-21,26-27H2,1H3,(H,28,31);2*1H/t22?,23-;;/m0../s1
InChI key
RISSBZWRJRRXTD-OLBPYZPGSA-N
Application
NPC-15437 dihydrochloride hydrate has been used as a protein kinase C (PKC) inhibitor:
- to test its blocking effect on nicotine-seeking behavior in mice in drug-paired cues[1]
- along with cocaine to test its effect on 3,4-methylenedioxymethamphetamine (MDMA)-induced neurotoxicity in mice[2]
- to study its effect on PKC signaling in object recognition memory studies[3]
Biochem/physiol Actions
NPC 15437 is also reported to be a P-glycoprotein (Pgp) modulator.[4]
Selective protein kinase C inhibitor.
Features and Benefits
This compound is featured on the PKC page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Classe di stoccaggio
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Ainhoa Plaza-Zabala et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 38(9), 1724-1736 (2013-03-23)
Hypocretin/orexin signaling is critically involved in relapse to drug-seeking behaviors. In this study, we investigated the involvement of the hypocretin system in the reinstatement of nicotine-seeking behavior induced by nicotine-associated cues. Pretreatment with the hypocretin receptor-1 antagonist SB334867, but not
J P Sullivan et al.
Molecular pharmacology, 41(1), 38-44 (1992-01-01)
NPC 15437 is a prototype member of a new class of synthetically derived protein kinase C (PKC) inhibitors. PKC activity and binding of phorbol ester to the enzyme were inhibited by NPC 15437, with IC50 values of 19 +/- 2
E C Sha et al.
Investigational new drugs, 13(4), 285-294 (1996-01-01)
We assessed the effect of the protein kinase C inhibitor 2,6-diamino-N-([1-(1-oxotridecyl)-2-piperidinyl]methyl)hexanami de (NPC 15437) on the action of anthracyclines, epipodophyllotoxins and vinca alkaloids in P-glycoprotein (Pgp)-expressing CH(R)C5 hamster ovary and MCF-7/Adria(R) human breast cancer cells. Flow microfluorimetry revealed that treatment
Numero articolo commerciale globale
| SKU | GTIN |
|---|---|
| N161-25MG | 04061832272566 |
| N161-5MG | 04061832449029 |