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N129

Naloxone methiodide

≥98% (HPLC), opioid receptor inhibitor, solid

Sinonimo/i:

(5α,17R)-4,5-Epoxy-3,14-dihydroxy-17-methyl-6-oxo-17-(2-propenyl)-morphinanium iodide, N-Methylnaloxonium iodide

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Cambia visualizzazione
Taglio della confezioneSKUDisponibilitàPrezzo
25 mg
Per conoscere la disponibilità, visualizza il carrello
CHF 99.20
100 mg
Per conoscere la disponibilità, visualizza il carrello
CHF 298.00
250 mg
Per conoscere la disponibilità, visualizza il carrello
CHF 620.00
CHF 527.00

Informazioni su questo articolo

Formula empirica (notazione di Hill):
C20H24INO4
Numero CAS:
93302-47-7
Peso molecolare:
469.31
UNSPSC Code:
12352200
PubChem Substance ID:
24897480
NACRES:
NA.77
MDL number:
MFCD00078592
Assay:
≥98% (HPLC)
Form:
solid
Quality level:
100

CHF 99.20

Per conoscere la disponibilità, visualizza il carrello
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Nome del prodotto

Naloxone methiodide, ≥98% (HPLC), solid

Quality Level

100

assay

≥98% (HPLC)

form

solid

drug control

regulated under CDSA - not available from Sigma-Aldrich Canada

color

white to tan

solubility

H2O: >10 mg/mL

storage temp.

2-8°C

SMILES string

[I-].[H][C@]12Oc3c(O)ccc4C[C@@H]5[C@](O)(CCC1=O)[C@@]2(CC[N@+]5(C)CC=C)c34

InChI

1S/C20H23NO4.HI/c1-3-9-21(2)10-8-19-16-12-4-5-13(22)17(16)25-18(19)14(23)6-7-20(19,24)15(21)11-12;/h3-5,15,18,24H,1,6-11H2,2H3;1H/t15-,18+,19+,20-,21?;/m1./s1

InChI key

ICONPJDAXITIPI-UXYWFNEESA-N

Application

Naloxone methiodide has been used as inhibitor of opioid receptor in fish and mice. Naloxone methiodide has been used to block opioid neurotransmission.

Biochem/physiol Actions

Naloxone methiodide has low affinity for opioid receptors than naloxone. Administration of naloxone inhibits opioid receptor and opioid-induced respiratory depression.
Quaternary salt of naloxone that, like the parent compound, is a nonselective antagonist at opioid receptors. It does not cross the blood-brain barrier.

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Questo articolo
N165N9412O003
Naloxone methiodide ≥98% (HPLC), solid

Sigma-Aldrich

N129

Naloxone methiodide

Naloxone benzoylhydrazone solid

Sigma-Aldrich

N165

Naloxone benzoylhydrazone

6β-Naltrexol hydrate ≥96% (HPLC), powder

Sigma-Aldrich

N9412

6β-Naltrexol hydrate

β-Funaltrexamine hydrochloride solid

Sigma-Aldrich

O003

β-Funaltrexamine hydrochloride

assay

≥98% (HPLC)

assay

-

assay

≥96% (HPLC)

assay

-

form

solid

form

solid

form

powder

form

solid

drug control

regulated under CDSA - not available from Sigma-Aldrich Canada

drug control

regulated under CDSA - not available from Sigma-Aldrich Canada

drug control

regulated under CDSA - not available from Sigma-Aldrich Canada

drug control

regulated under CDSA - not available from Sigma-Aldrich Canada

Quality Level

100

Quality Level

-

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

−20°C

solubility

H2O: >10 mg/mL

solubility

DMSO: soluble, H2O: soluble (with the addition of 0.1 N HCl), ethanol: soluble

solubility

DMSO: ~12 mg/mL, H2O: insoluble

solubility

H2O: 7.5 mg/mL (aqueous solutions should be promptly used), methanol: 7.6 mg/mL (do not store in ethanolic solution; methanolic solutions may be stored for several weeks at 4 °C)

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Classe di stoccaggio

11 - Combustible Solids

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificati d'analisi (COA)

Lot/Batch Number
0000539776
0000539778
0000539776
0000539778
0000406397

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Delta opioid receptors are essential to the antiallodynic action of Β2-mimetics in a model of neuropathic pain.
Mélanie Kremer et al.
Molecular pain, 16, 1744806920912931-1744806920912931 (2020-03-27)
Helvira Melo et al.
Scientific reports, 8(1), 15551-15551 (2018-10-21)
Opioids remain the gold standard for the treatment of moderate to severe pain. However, their analgesic properties come with important side effects, including pruritus, which occurs frequently after systemic or neuraxial administration. Although part of the opioid-induced itch is mediated
Naloxone methiodide reverses opioid-induced respiratory depression and analgesia without withdrawal
Lewanowitsch Tanya and Irvine RJ
European Journal of Pharmacology, 445(1-2), 61 -667 (2002)
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Numero articolo commerciale globale

SKUGTIN
N129-250MG04061832557380
N129-100MG04061832557373
N129-25MG04061832557397

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